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An imaging biomarker to detect non-glucogenic shift in brain energy metabolism in Alzheimer's disease.

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Title: An imaging biomarker to detect non-glucogenic shift in brain energy metabolism in Alzheimer's disease.
Authors: Soni ND; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA., Swain A; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA.; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA, 19104, USA., Khokhar SK; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA., Wilson NE; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA., Nanga RPR; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA., Kumar D; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA., Bouche E; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA, 19104, USA., Cao Q; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA, 19104, USA., Haris M; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA., Wolk DA; Alzheimer's Disease Research Center, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA., Lee VM; Alzheimer's Disease Research Center, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.; Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA, 19104, USA., Detre JA; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.; Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA, 19104, USA., Reddy R; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA. krr@pennmedicine.upenn.edu.
Source: Journal of translational medicine [J Transl Med] 2026 May 20; Vol. 24 (1). Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An imaging biomarker to detect non-glucogenic shift in brain energy metabolism in Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Soni+ND%22">Soni ND</searchLink>; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Swain+A%22">Swain A</searchLink>; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA.; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Khokhar+SK%22">Khokhar SK</searchLink>; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+NE%22">Wilson NE</searchLink>; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Nanga+RPR%22">Nanga RPR</searchLink>; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+D%22">Kumar D</searchLink>; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Bouche+E%22">Bouche E</searchLink>; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Cao+Q%22">Cao Q</searchLink>; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Haris+M%22">Haris M</searchLink>; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Wolk+DA%22">Wolk DA</searchLink>; Alzheimer's Disease Research Center, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Lee+VM%22">Lee VM</searchLink>; Alzheimer's Disease Research Center, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.; Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Detre+JA%22">Detre JA</searchLink>; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.; Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Reddy+R%22">Reddy R</searchLink>; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 422 Curie Boulevard, B1 Stellar-Chance Labs, Philadelphia, PA, 19104, USA. krr@pennmedicine.upenn.edu.
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