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Metabolic health effects of the timing of lifestyle behaviours in a combined lifestyle intervention in adults who have obesity or are overweight with complications: protocol for a two-armed, cluster-randomized, pragmatic trial-a TIMED study.

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Title: Metabolic health effects of the timing of lifestyle behaviours in a combined lifestyle intervention in adults who have obesity or are overweight with complications: protocol for a two-armed, cluster-randomized, pragmatic trial-a TIMED study.
Authors: Slebe R; Department of Epidemiology and Data Science, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. r.slebe@amsterdamumc.nl.; Amsterdam Public Health, Health Behaviours & Chronic Diseases, Amsterdam, The Netherlands. r.slebe@amsterdamumc.nl., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Després JP; Department of Kinesiology, Université Laval and Centre de Recherche Sur Les Soins Et Les Services de Première Ligne, Québec, QC, Canada., Campbell DJT; Department of Medicine, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.; Department of Community Health Sciences, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.; Department of Cardiac Sciences, University of Calgary Cumming School of Medicine, Calgary, AB, Canada., Kalsbeek A; Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands.; Netherlands Institute for Neuroscience (NIN), Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands., Schrauwen P; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Beulens JWJ; Department of Epidemiology and Data Science, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Health Behaviours & Chronic Diseases, Amsterdam, The Netherlands., Rutters F; Department of Epidemiology and Data Science, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Health Behaviours & Chronic Diseases, Amsterdam, The Netherlands.
Corporate Authors: on behalf of the TIMED consortium
Source: Trials [Trials] 2026 May 20; Vol. 27 (1). Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Metabolic health effects of the timing of lifestyle behaviours in a combined lifestyle intervention in adults who have obesity or are overweight with complications: protocol for a two-armed, cluster-randomized, pragmatic trial-a TIMED study.
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  Data: <searchLink fieldCode="AU" term="%22Slebe+R%22">Slebe R</searchLink>; Department of Epidemiology and Data Science, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. r.slebe@amsterdamumc.nl.; Amsterdam Public Health, Health Behaviours & Chronic Diseases, Amsterdam, The Netherlands. r.slebe@amsterdamumc.nl.<br /><searchLink fieldCode="AU" term="%22de+Mutsert+R%22">de Mutsert R</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Després+JP%22">Després JP</searchLink>; Department of Kinesiology, Université Laval and Centre de Recherche Sur Les Soins Et Les Services de Première Ligne, Québec, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Campbell+DJT%22">Campbell DJT</searchLink>; Department of Medicine, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.; Department of Community Health Sciences, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.; Department of Cardiac Sciences, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Kalsbeek+A%22">Kalsbeek A</searchLink>; Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands.; Netherlands Institute for Neuroscience (NIN), Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Schrauwen+P%22">Schrauwen P</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Beulens+JWJ%22">Beulens JWJ</searchLink>; Department of Epidemiology and Data Science, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Health Behaviours & Chronic Diseases, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rutters+F%22">Rutters F</searchLink>; Department of Epidemiology and Data Science, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Health Behaviours & Chronic Diseases, Amsterdam, The Netherlands.
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              Text: 2026 May 20
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