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In vitro and in vivo antibacterial activity of oral tebipenem in combination with novel β-lactamase inhibitors (avibactam, relebactam, vaborbactam) against KPC-producing Enterobacterales.

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Title: In vitro and in vivo antibacterial activity of oral tebipenem in combination with novel β-lactamase inhibitors (avibactam, relebactam, vaborbactam) against KPC-producing Enterobacterales.
Authors: Zou C; Department of Clinical Laboratory, University-Town Hospital of Chongqing Medical University, Chongqing, China., Shen J; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Shang L; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Wang W; Department of Laboratory Medicine, The Second Affiliated Hospital of Chengdu Medical College (Nuclear Industry 416 Hospital), Chengdu, China., Li X; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Yu J; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Li Y; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Laboratory Medicine, Chongqing Medical University, Chongqing, China., Xu W; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., He Q; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Chen L; Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, 14214, USA., Ge Q; Department of Hematology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Haishu District, Ningbo, Zhejiang Province, 315010, China., Wang D; Department of Laboratory Medicine, Chongqing Medical University, Chongqing, China., Wang S; Department of Dermatology and Cosmetology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China. 987877607@qq.com., Niu S; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. siqiangniu@cqmu.edu.cn.
Source: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 8804297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-4373 (Electronic) Linking ISSN: 09349723 NLM ISO Abbreviation: Eur J Clin Microbiol Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In vitro and in vivo antibacterial activity of oral tebipenem in combination with novel β-lactamase inhibitors (avibactam, relebactam, vaborbactam) against KPC-producing Enterobacterales.
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  Data: <searchLink fieldCode="AU" term="%22Zou+C%22">Zou C</searchLink>; Department of Clinical Laboratory, University-Town Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Shen+J%22">Shen J</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Shang+L%22">Shang L</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Laboratory Medicine, The Second Affiliated Hospital of Chengdu Medical College (Nuclear Industry 416 Hospital), Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Laboratory Medicine, Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Xu+W%22">Xu W</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22He+Q%22">He Q</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, 14214, USA.<br /><searchLink fieldCode="AU" term="%22Ge+Q%22">Ge Q</searchLink>; Department of Hematology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Haishu District, Ningbo, Zhejiang Province, 315010, China.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Department of Laboratory Medicine, Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Dermatology and Cosmetology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China. 987877607@qq.com.<br /><searchLink fieldCode="AU" term="%22Niu+S%22">Niu S</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. siqiangniu@cqmu.edu.cn.
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