Efficacy and Safety of SPH3127 Tablet, a Novel Direct Renin Inhibitor, in Patients with Mild-to-Moderate Essential Hypertension: A Phase III Randomised Trial.

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Title: Efficacy and Safety of SPH3127 Tablet, a Novel Direct Renin Inhibitor, in Patients with Mild-to-Moderate Essential Hypertension: A Phase III Randomised Trial.
Authors: Lv Q; Department of Cardiovascular Medicine II, Beijing Anzhen Hospital Capital Medical University, Beijing, China., Ma C; Department of Cardiovascular Medicine II, Beijing Anzhen Hospital Capital Medical University, Beijing, China. chshma@vip.sina.com., Wang F; Department of Cardiovascular Medicine II, Beijing Hospital, Beijing, China., Li L; Department of Cardiovascular Medicine, The Third People's Hospital of Luoyang City, Luoyang, China., Xiong G; Department of Cardiovascular Medicine, People's Hospital Affiliated to Chongqing Three Gorges Medical College, Chongqing, China., Li Z; Department of Cardiovascular Medicine, The People's Hospital of Liaoning Province, Shenyang, China., Qu Y; Department of Cardiovascular Medicine II, Yuncheng Central Hospital, Yuncheng, China., Pang W; Department of Cardiovascular Medicine III, Shengjing Hospital of China Medical University, Shengyang, China., Xiao W; Department of Cardiovascular Medicine I, Hebei Medical University Third Hospital, Shijiazhuang, China., Ruan H; Department of Cardiovascular Medicine, Xuzhou Central Hospital, Xuzhou, China., Wei L; Department of Cardiovascular Medicine, Tianjin People's Hospital, Tianjin, China., Liu G; Department of Cardiovascular Medicine, The First Hospital of Hebei Medical University, Shijiazhuang, China., Zhang J; Department of Cardiovascular Medicine, Cangzhou Central Hospital, Cangzhou, China., Liu Q; Department of Cardiovascular Medicine, Xiangya Hospital of Central South University, Changsha, China., Lin L; Department of Cardiovascular Medicine, The Third People's Hospital of Hainan Province, Sanya, China., Long M; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China., Li H; Department of Cardiovascular Medicine, The Fourth Central Hospital of Tianjin City, Tianjin, China., Yuan H; Department of Cardiovascular Medicine, The Third Xiangya Hospital of Central South University, Changsha, China., Liu L; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, China., Gao Y; Geriatrics Department, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China., Liu P; Department of Cardiovascular Medicine, Affiliated Hospital of Jiangsu University, Zhengjiang, China., Zhang C; Comprehensive Medical Department, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China., Wang Z; Department of Cardiovascular Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Xie J; Cadre's Wards, Zhejiang Provincial People's Hospital, Hangzhou, China., Wang J; Hypertension Department, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhang X; Department of Cardiovascular MedicineThe First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China., Lu Y; Department of Cardiovascular Medicine, Suzhou Municipal Hospital, Suzhou, China., Huang K; Department of Cardiovascular Medicine, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China., Liu M; Hypertension Department, Henan Provincial People's Hospital, Zhengzhou, China., Chen J; Department of Cardiovascular Medicine, Guangdong Provincial People's Hospital, Guangzhou, China., Gao X; Internal Medicine, Pinggu District Hospital of Beijing City, Beijing, China., Wang D; Department of Cardiovascular Medicine, Chifeng City Hospital, Chifeng, China., Ma X; Cardiology Department of the Heart Canter, General Hospital of Ningxia Medical University, Yinchuan, China., Chen X; Department of Cardiovascular Medicine, West China Hospital of Sichuan University, Chengdu, China., Li Y; Department of Cardiovascular Medicine I, Guangdong Second Provincial General Hospital, Guangzhou, China., Zhang Y; Department of Cardiovascular Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China., Kong X; Department of Cardiovascular Medicine, Jiangsu Province Hospital, Nanjing, China., Chen F; Department of Cardiovascular Medicine A, The First People's Hospital of Yinchuan City, Yinchuang, China., Zhang X; Department of Cardiovascular Medicine II, The Second Hospital of Lanzhou University, Lanzhou, China., Qi J; Department of Cardiovascular Medicine, Liuzhou People's Hospital, Liuzhou, China., Cao Y; Shanghai Pharmaceutical Holding Co., Ltd., Shanghai, China., Huang Y; Shanghai Pharmaceutical Holding Co., Ltd., Shanghai, China., Zhang Y; Shanghai Pharmaceutical Holding Co., Ltd., Shanghai, China., Cui W; Shanghai Pharmaceutical Holding Co., Ltd., Shanghai, China.
Source: Drugs [Drugs] 2026 Jul; Vol. 86 (7), pp. 1121-1132. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 7600076 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1950 (Electronic) Linking ISSN: 00126667 NLM ISO Abbreviation: Drugs Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1179-1950
DOI:10.1007/s40265-026-02315-z