Efficacy and Safety of SPH3127 Tablet, a Novel Direct Renin Inhibitor, in Patients with Mild-to-Moderate Essential Hypertension: A Phase III Randomised Trial.
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| Title: | Efficacy and Safety of SPH3127 Tablet, a Novel Direct Renin Inhibitor, in Patients with Mild-to-Moderate Essential Hypertension: A Phase III Randomised Trial. |
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| Authors: | Lv Q; Department of Cardiovascular Medicine II, Beijing Anzhen Hospital Capital Medical University, Beijing, China., Ma C; Department of Cardiovascular Medicine II, Beijing Anzhen Hospital Capital Medical University, Beijing, China. chshma@vip.sina.com., Wang F; Department of Cardiovascular Medicine II, Beijing Hospital, Beijing, China., Li L; Department of Cardiovascular Medicine, The Third People's Hospital of Luoyang City, Luoyang, China., Xiong G; Department of Cardiovascular Medicine, People's Hospital Affiliated to Chongqing Three Gorges Medical College, Chongqing, China., Li Z; Department of Cardiovascular Medicine, The People's Hospital of Liaoning Province, Shenyang, China., Qu Y; Department of Cardiovascular Medicine II, Yuncheng Central Hospital, Yuncheng, China., Pang W; Department of Cardiovascular Medicine III, Shengjing Hospital of China Medical University, Shengyang, China., Xiao W; Department of Cardiovascular Medicine I, Hebei Medical University Third Hospital, Shijiazhuang, China., Ruan H; Department of Cardiovascular Medicine, Xuzhou Central Hospital, Xuzhou, China., Wei L; Department of Cardiovascular Medicine, Tianjin People's Hospital, Tianjin, China., Liu G; Department of Cardiovascular Medicine, The First Hospital of Hebei Medical University, Shijiazhuang, China., Zhang J; Department of Cardiovascular Medicine, Cangzhou Central Hospital, Cangzhou, China., Liu Q; Department of Cardiovascular Medicine, Xiangya Hospital of Central South University, Changsha, China., Lin L; Department of Cardiovascular Medicine, The Third People's Hospital of Hainan Province, Sanya, China., Long M; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China., Li H; Department of Cardiovascular Medicine, The Fourth Central Hospital of Tianjin City, Tianjin, China., Yuan H; Department of Cardiovascular Medicine, The Third Xiangya Hospital of Central South University, Changsha, China., Liu L; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, China., Gao Y; Geriatrics Department, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China., Liu P; Department of Cardiovascular Medicine, Affiliated Hospital of Jiangsu University, Zhengjiang, China., Zhang C; Comprehensive Medical Department, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China., Wang Z; Department of Cardiovascular Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Xie J; Cadre's Wards, Zhejiang Provincial People's Hospital, Hangzhou, China., Wang J; Hypertension Department, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhang X; Department of Cardiovascular MedicineThe First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China., Lu Y; Department of Cardiovascular Medicine, Suzhou Municipal Hospital, Suzhou, China., Huang K; Department of Cardiovascular Medicine, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China., Liu M; Hypertension Department, Henan Provincial People's Hospital, Zhengzhou, China., Chen J; Department of Cardiovascular Medicine, Guangdong Provincial People's Hospital, Guangzhou, China., Gao X; Internal Medicine, Pinggu District Hospital of Beijing City, Beijing, China., Wang D; Department of Cardiovascular Medicine, Chifeng City Hospital, Chifeng, China., Ma X; Cardiology Department of the Heart Canter, General Hospital of Ningxia Medical University, Yinchuan, China., Chen X; Department of Cardiovascular Medicine, West China Hospital of Sichuan University, Chengdu, China., Li Y; Department of Cardiovascular Medicine I, Guangdong Second Provincial General Hospital, Guangzhou, China., Zhang Y; Department of Cardiovascular Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China., Kong X; Department of Cardiovascular Medicine, Jiangsu Province Hospital, Nanjing, China., Chen F; Department of Cardiovascular Medicine A, The First People's Hospital of Yinchuan City, Yinchuang, China., Zhang X; Department of Cardiovascular Medicine II, The Second Hospital of Lanzhou University, Lanzhou, China., Qi J; Department of Cardiovascular Medicine, Liuzhou People's Hospital, Liuzhou, China., Cao Y; Shanghai Pharmaceutical Holding Co., Ltd., Shanghai, China., Huang Y; Shanghai Pharmaceutical Holding Co., Ltd., Shanghai, China., Zhang Y; Shanghai Pharmaceutical Holding Co., Ltd., Shanghai, China., Cui W; Shanghai Pharmaceutical Holding Co., Ltd., Shanghai, China. |
| Source: | Drugs [Drugs] 2026 Jul; Vol. 86 (7), pp. 1121-1132. Date of Electronic Publication: 2026 May 21. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study |
| Journal Info: | Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 7600076 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1950 (Electronic) Linking ISSN: 00126667 NLM ISO Abbreviation: Drugs Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42165988 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Efficacy and Safety of SPH3127 Tablet, a Novel Direct Renin Inhibitor, in Patients with Mild-to-Moderate Essential Hypertension: A Phase III Randomised Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lv+Q%22">Lv Q</searchLink>; Department of Cardiovascular Medicine II, Beijing Anzhen Hospital Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Ma+C%22">Ma C</searchLink>; Department of Cardiovascular Medicine II, Beijing Anzhen Hospital Capital Medical University, Beijing, China. chshma@vip.sina.com.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Department of Cardiovascular Medicine II, Beijing Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Cardiovascular Medicine, The Third People's Hospital of Luoyang City, Luoyang, China.<br /><searchLink fieldCode="AU" term="%22Xiong+G%22">Xiong G</searchLink>; Department of Cardiovascular Medicine, People's Hospital Affiliated to Chongqing Three Gorges Medical College, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Cardiovascular Medicine, The People's Hospital of Liaoning Province, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Qu+Y%22">Qu Y</searchLink>; Department of Cardiovascular Medicine II, Yuncheng Central Hospital, Yuncheng, China.<br /><searchLink fieldCode="AU" term="%22Pang+W%22">Pang W</searchLink>; Department of Cardiovascular Medicine III, Shengjing Hospital of China Medical University, Shengyang, China.<br /><searchLink fieldCode="AU" term="%22Xiao+W%22">Xiao W</searchLink>; Department of Cardiovascular Medicine I, Hebei Medical University Third Hospital, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Ruan+H%22">Ruan H</searchLink>; Department of Cardiovascular Medicine, Xuzhou Central Hospital, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Wei+L%22">Wei L</searchLink>; Department of Cardiovascular Medicine, Tianjin People's Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Liu+G%22">Liu G</searchLink>; Department of Cardiovascular Medicine, The First Hospital of Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Cardiovascular Medicine, Cangzhou Central Hospital, Cangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Department of Cardiovascular Medicine, Xiangya Hospital of Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Lin+L%22">Lin L</searchLink>; Department of Cardiovascular Medicine, The Third People's Hospital of Hainan Province, Sanya, China.<br /><searchLink fieldCode="AU" term="%22Long+M%22">Long M</searchLink>; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Cardiovascular Medicine, The Fourth Central Hospital of Tianjin City, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Yuan+H%22">Yuan H</searchLink>; Department of Cardiovascular Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Geriatrics Department, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; Department of Cardiovascular Medicine, Affiliated Hospital of Jiangsu University, Zhengjiang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Comprehensive Medical Department, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Cardiovascular Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; Cadre's Wards, Zhejiang Provincial People's Hospital, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Hypertension Department, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Cardiovascular MedicineThe First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Cardiovascular Medicine, Suzhou Municipal Hospital, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+K%22">Huang K</searchLink>; Department of Cardiovascular Medicine, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Hypertension Department, Henan Provincial People's Hospital, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Cardiovascular Medicine, Guangdong Provincial People's Hospital, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Gao+X%22">Gao X</searchLink>; Internal Medicine, Pinggu District Hospital of Beijing City, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Department of Cardiovascular Medicine, Chifeng City Hospital, Chifeng, China.<br /><searchLink fieldCode="AU" term="%22Ma+X%22">Ma X</searchLink>; Cardiology Department of the Heart Canter, General Hospital of Ningxia Medical University, Yinchuan, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Cardiovascular Medicine, West China Hospital of Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Cardiovascular Medicine I, Guangdong Second Provincial General Hospital, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Cardiovascular Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.<br /><searchLink fieldCode="AU" term="%22Kong+X%22">Kong X</searchLink>; Department of Cardiovascular Medicine, Jiangsu Province Hospital, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Department of Cardiovascular Medicine A, The First People's Hospital of Yinchuan City, Yinchuang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Cardiovascular Medicine II, The Second Hospital of Lanzhou University, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; Department of Cardiovascular Medicine, Liuzhou People's Hospital, Liuzhou, China.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Shanghai Pharmaceutical Holding Co., Ltd., Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Shanghai Pharmaceutical Holding Co., Ltd., Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Shanghai Pharmaceutical Holding Co., Ltd., Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Cui+W%22">Cui W</searchLink>; Shanghai Pharmaceutical Holding Co., Ltd., Shanghai, China. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227600076%22">Drugs</searchLink> [Drugs] 2026 Jul; Vol. 86 (7), pp. 1121-1132. <i>Date of Electronic Publication: </i>2026 May 21. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Adis%2C+Springer+International%22">Adis, Springer International </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>7600076 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1179-1950 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200126667%22">00126667 </searchLink><i>NLM ISO Abbreviation: </i>Drugs <i>Subsets: </i>MEDLINE |
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