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Lentiviral-mediated expression of cytochrome P450 2D6 in HepaRG cells: new means for in vitro xenobiotic biotransformation and cellular response to chimeric viral mRNA.

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Title: Lentiviral-mediated expression of cytochrome P450 2D6 in HepaRG cells: new means for in vitro xenobiotic biotransformation and cellular response to chimeric viral mRNA.
Authors: Coppens-Exandier H; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.; Biopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France., Mackanga F; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France., Darde T; SciLicium, 10 rue de la Sauvaie, 35000, Rennes, France., Bonhomme C; SciLicium, 10 rue de la Sauvaie, 35000, Rennes, France., Angenard G; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France., Leroyer P; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France., Ribault C; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.; Plateforme BiogenOuest SynNanoVect, Brest, France., Gicquel T; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.; Laboratoire de toxicologie médico-légale, CHU Rennes, F-35000, Rennes, France., Pelletier R; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.; Laboratoire de toxicologie médico-légale, CHU Rennes, F-35000, Rennes, France., Roshchina F; Biopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France., Schaefer E; Biopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France., Chesné C; Biopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France., Jamin A; Biopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France., Corlu A; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France., Loyer P; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France. pascal.loyer@univ-rennes.fr.; Plateforme BiogenOuest SynNanoVect, Brest, France. pascal.loyer@univ-rennes.fr.
Source: Archives of toxicology [Arch Toxicol] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
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  Data: Lentiviral-mediated expression of cytochrome P450 2D6 in HepaRG cells: new means for in vitro xenobiotic biotransformation and cellular response to chimeric viral mRNA.
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  Data: <searchLink fieldCode="AU" term="%22Coppens-Exandier+H%22">Coppens-Exandier H</searchLink>; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.; Biopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France.<br /><searchLink fieldCode="AU" term="%22Mackanga+F%22">Mackanga F</searchLink>; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Darde+T%22">Darde T</searchLink>; SciLicium, 10 rue de la Sauvaie, 35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Bonhomme+C%22">Bonhomme C</searchLink>; SciLicium, 10 rue de la Sauvaie, 35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Angenard+G%22">Angenard G</searchLink>; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Leroyer+P%22">Leroyer P</searchLink>; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Ribault+C%22">Ribault C</searchLink>; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.; Plateforme BiogenOuest SynNanoVect, Brest, France.<br /><searchLink fieldCode="AU" term="%22Gicquel+T%22">Gicquel T</searchLink>; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.; Laboratoire de toxicologie médico-légale, CHU Rennes, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Pelletier+R%22">Pelletier R</searchLink>; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.; Laboratoire de toxicologie médico-légale, CHU Rennes, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Roshchina+F%22">Roshchina F</searchLink>; Biopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France.<br /><searchLink fieldCode="AU" term="%22Schaefer+E%22">Schaefer E</searchLink>; Biopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France.<br /><searchLink fieldCode="AU" term="%22Chesné+C%22">Chesné C</searchLink>; Biopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France.<br /><searchLink fieldCode="AU" term="%22Jamin+A%22">Jamin A</searchLink>; Biopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France.<br /><searchLink fieldCode="AU" term="%22Corlu+A%22">Corlu A</searchLink>; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Loyer+P%22">Loyer P</searchLink>; Institut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France. pascal.loyer@univ-rennes.fr.; Plateforme BiogenOuest SynNanoVect, Brest, France. pascal.loyer@univ-rennes.fr.
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