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Frailty and intrinsic capacity: integrating complementary concepts to promote healthy ageing and transformation of care.

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Title: Frailty and intrinsic capacity: integrating complementary concepts to promote healthy ageing and transformation of care.
Authors: Cesari M; Ageing and Health Unit, Department of Maternal, Child, Newborn, Adolescent Health and Ageing, World Health Organization, Avenue Appia 20, 1211 Geneva 27,  Switzerland., Canevelli M; Department of Human Neuroscience, Sapienza University, Rome, Lazio 0185, Italy., Amuthavalli Thiyagarajan J; Ageing and Health Unit, Department of Maternal, Child, Newborn, Adolescent Health and Ageing, World Health Organization, Avenue Appia 20, 1211 Geneva 27,  Switzerland., Arai H; National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi 484-0038, Japan., Assantachai P; Faculty of Medicine, Mahidol University and Siriraj Hospital, Bangkok City 10700, Thailand., Chan P; National Clinical Research Center for Geriatric Disorders: Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053,Beijing, China., Chhetri JK; National Clinical Research Center for Geriatric Disorders: Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053,Beijing, China.; Nepalese Society of Gerontology and Geriatrics, Bhaktapur, Ward 3, Bhaktapur, Nepal., Ferriolli E; Division of Geriatrics, Department of Internal Medicine, University of São Paulo Medical School, Avenida Professor Luciano Gualberto, 908, São Paulo, São Paulo, SP, Brazil., Geffen L; The Albertina and Walter Sisulu Institute of Ageing in Africa, Department of Medicine, University of Cape Town, Western Cape, 7935, Cape Town, South Africa., Gregson CL; Global Health and Ageing Research Unit, University of Bristol, Level 1 Learning and Research Building, Southmead Hospital, BS10 5NB, Bristol, UK.; The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, 10 Seagrave Avondale, Harare, Zimbabwe., Guaraldi G; Department of Surgical, Medical, Dental, and Morphological Sciences, University of Modena and Reggio Emilia, Via Università 4 - 41121, Modena, Emilia-Romagna, Italy., Gutierrez Robledo LM; Instituto Nacional de Geriatría, Av. Contreras 428 Col. San Jerónimo Lídice 10200, Mexico City, Mexico., Hammami S; Department of Internal Medicine and Research Laboratory LR 12ES05, University of Monastir, Avenue Taher Hadded B.P. 56, Monastir, Tunisia., Jang H; Ageing and Health Unit, Department of Maternal, Child, Newborn, Adolescent Health and Ageing, World Health Organization, Avenue Appia 20, 1211 Geneva 27,  Switzerland., Kalula S; The Albertina and Walter Sisulu Institute of Ageing in Africa, Department of Medicine, University of Cape Town, Western Cape, 7935, Cape Town, South Africa., Mathur A; Asian Centre for Medical Education Research & Innovation, SN Medical College, Shastri Nagar, Residency Road, Jodhpur, Rajasthan 342001, India., Merchant RA; Department of Medicine, National University Hospital, 21 Lower Kent Ridge Road Singapore 119077, Singapore., Oliveira D; Faculty of Nursing, Universidad Andrés Bello, 121,Avenida Bellavista 8420507 Santiago Metropolitana de Santiago, Santiago, Chile.; Millenium Institute for Care Research (MICARE), Avenue Libertador Bernardo O´Higgins 340, Casa Central, Santiago, Chile., Perracini MR; Master's and Doctoral Program in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno, 448/475, Tatuapé, Sao Paulo, SP, Brazil., Petrovic M; Section of Geriatrics; Department of Internal Medicine and Paediatrics, Ghent University, Gent 9000, Belgium., Polidori-Nelles MC; Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine, University Hospital Cologne, Kerpener Str 62 · 50937 Cologne,, Germany.; Cologne Excellence Cluster on Aging and Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Rodriguez Mañas L; Servicio de Geriatría, Hospital Universitario de Getafe, Calle Toledo 12, 28901, Getafe (Comunidad de Madrid), Madrid 28905, Spain., Rowe JW; The Columbia Aging Center and the Department of Health Policy and Management Mailman, School of Public Health, Columbia University, , 722 W 168th St, New York, NY 10032, USA., Sabzwari S; Department of Family Medicine, The Aga Khan University, Stadium Road, P.O. Box 3500, Karachi 74800, Sindh, Pakistan., Sadana R; Ageing and Health Unit, Department of Maternal, Child, Newborn, Adolescent Health and Ageing, World Health Organization, Avenue Appia 20, 1211 Geneva 27,  Switzerland., Sumi Y; Ageing and Health Unit, Department of Maternal, Child, Newborn, Adolescent Health and Ageing, World Health Organization, Avenue Appia 20, 1211 Geneva 27,  Switzerland., Tomarevska O; D.F. Chebotarev Institute of Gerontology of the National Academy of the Medical Sciences of Ukraine Kyiv, vulytsia Volodymyrska, 54 Kyiv City, Ukraine., Vellas B; IHU HealthAge, Gérontopôle de Toulouse, Centre Hospitalo-Universitaire de Toulouse, 2 Rue Viguerie, 31300, Toulouse, France.; CERPOP, UPS/Inserm 1295, 37 Allées Jules Guesde, 31400 Toulouse, France., Visvanathan R; Adelaide Geriatrics Training and Research with Aged Care (GTRAC) Centre; School of Medicine, College of Health, Adelaide University, 4 North Terrace, Adelaide South Australia 5000, Australia.; Basil Hetzel Institute, Central Adelaide Local Health Network, 37A Woodville Rd, Adelaide South Australia 5011, Australia., Woo J; Jockey Club Institute of Ageing, Suite 602, 6/F, Yasumoto International Academic Park, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China., Martin FC; Faculty of Life Sciences & Medicine, Population Health Sciences, King's College London, Great Maze Pond, London SE1 9RT, UK.
Source: Age and ageing [Age Ageing] 2026 May 04; Vol. 55 (5).
Publication Type: Journal Article; Review
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0375655 Publication Model: Print Cited Medium: Internet ISSN: 1468-2834 (Electronic) Linking ISSN: 00020729 NLM ISO Abbreviation: Age Ageing Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Frailty and intrinsic capacity: integrating complementary concepts to promote healthy ageing and transformation of care.
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  Data: <searchLink fieldCode="AU" term="%22Cesari+M%22">Cesari M</searchLink>; Ageing and Health Unit, Department of Maternal, Child, Newborn, Adolescent Health and Ageing, World Health Organization, Avenue Appia 20, 1211 Geneva 27,  Switzerland.<br /><searchLink fieldCode="AU" term="%22Canevelli+M%22">Canevelli M</searchLink>; Department of Human Neuroscience, Sapienza University, Rome, Lazio 0185, Italy.<br /><searchLink fieldCode="AU" term="%22Amuthavalli+Thiyagarajan+J%22">Amuthavalli Thiyagarajan J</searchLink>; Ageing and Health Unit, Department of Maternal, Child, Newborn, Adolescent Health and Ageing, World Health Organization, Avenue Appia 20, 1211 Geneva 27,  Switzerland.<br /><searchLink fieldCode="AU" term="%22Arai+H%22">Arai H</searchLink>; National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi 484-0038, Japan.<br /><searchLink fieldCode="AU" term="%22Assantachai+P%22">Assantachai P</searchLink>; Faculty of Medicine, Mahidol University and Siriraj Hospital, Bangkok City 10700, Thailand.<br /><searchLink fieldCode="AU" term="%22Chan+P%22">Chan P</searchLink>; National Clinical Research Center for Geriatric Disorders: Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053,Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chhetri+JK%22">Chhetri JK</searchLink>; National Clinical Research Center for Geriatric Disorders: Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053,Beijing, China.; Nepalese Society of Gerontology and Geriatrics, Bhaktapur, Ward 3, Bhaktapur, Nepal.<br /><searchLink fieldCode="AU" term="%22Ferriolli+E%22">Ferriolli E</searchLink>; Division of Geriatrics, Department of Internal Medicine, University of São Paulo Medical School, Avenida Professor Luciano Gualberto, 908, São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Geffen+L%22">Geffen L</searchLink>; The Albertina and Walter Sisulu Institute of Ageing in Africa, Department of Medicine, University of Cape Town, Western Cape, 7935, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Gregson+CL%22">Gregson CL</searchLink>; Global Health and Ageing Research Unit, University of Bristol, Level 1 Learning and Research Building, Southmead Hospital, BS10 5NB, Bristol, UK.; The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, 10 Seagrave Avondale, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Guaraldi+G%22">Guaraldi G</searchLink>; Department of Surgical, Medical, Dental, and Morphological Sciences, University of Modena and Reggio Emilia, Via Università 4 - 41121, Modena, Emilia-Romagna, Italy.<br /><searchLink fieldCode="AU" term="%22Gutierrez+Robledo+LM%22">Gutierrez Robledo LM</searchLink>; Instituto Nacional de Geriatría, Av. 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San Jerónimo Lídice 10200, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Hammami+S%22">Hammami S</searchLink>; Department of Internal Medicine and Research Laboratory LR 12ES05, University of Monastir, Avenue Taher Hadded B.P. 56, Monastir, Tunisia.<br /><searchLink fieldCode="AU" term="%22Jang+H%22">Jang H</searchLink>; Ageing and Health Unit, Department of Maternal, Child, Newborn, Adolescent Health and Ageing, World Health Organization, Avenue Appia 20, 1211 Geneva 27,  Switzerland.<br /><searchLink fieldCode="AU" term="%22Kalula+S%22">Kalula S</searchLink>; The Albertina and Walter Sisulu Institute of Ageing in Africa, Department of Medicine, University of Cape Town, Western Cape, 7935, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Mathur+A%22">Mathur A</searchLink>; Asian Centre for Medical Education Research & Innovation, SN Medical College, Shastri Nagar, Residency Road, Jodhpur, Rajasthan 342001, India.<br /><searchLink fieldCode="AU" term="%22Merchant+RA%22">Merchant RA</searchLink>; Department of Medicine, National University Hospital, 21 Lower Kent Ridge Road Singapore 119077, Singapore.<br /><searchLink fieldCode="AU" term="%22Oliveira+D%22">Oliveira D</searchLink>; Faculty of Nursing, Universidad Andrés Bello, 121,Avenida Bellavista 8420507 Santiago Metropolitana de Santiago, Santiago, Chile.; Millenium Institute for Care Research (MICARE), Avenue Libertador Bernardo O´Higgins 340, Casa Central, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Perracini+MR%22">Perracini MR</searchLink>; Master's and Doctoral Program in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno, 448/475, Tatuapé, Sao Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Petrovic+M%22">Petrovic M</searchLink>; Section of Geriatrics; Department of Internal Medicine and Paediatrics, Ghent University, Gent 9000, Belgium.<br /><searchLink fieldCode="AU" term="%22Polidori-Nelles+MC%22">Polidori-Nelles MC</searchLink>; Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine, University Hospital Cologne, Kerpener Str 62 · 50937 Cologne,, Germany.; Cologne Excellence Cluster on Aging and Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Rodriguez+Mañas+L%22">Rodriguez Mañas L</searchLink>; Servicio de Geriatría, Hospital Universitario de Getafe, Calle Toledo 12, 28901, Getafe (Comunidad de Madrid), Madrid 28905, Spain.<br /><searchLink fieldCode="AU" term="%22Rowe+JW%22">Rowe JW</searchLink>; The Columbia Aging Center and the Department of Health Policy and Management Mailman, School of Public Health, Columbia University, , 722 W 168th St, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Sabzwari+S%22">Sabzwari S</searchLink>; Department of Family Medicine, The Aga Khan University, Stadium Road, P.O. Box 3500, Karachi 74800, Sindh, Pakistan.<br /><searchLink fieldCode="AU" term="%22Sadana+R%22">Sadana R</searchLink>; Ageing and Health Unit, Department of Maternal, Child, Newborn, Adolescent Health and Ageing, World Health Organization, Avenue Appia 20, 1211 Geneva 27,  Switzerland.<br /><searchLink fieldCode="AU" term="%22Sumi+Y%22">Sumi Y</searchLink>; Ageing and Health Unit, Department of Maternal, Child, Newborn, Adolescent Health and Ageing, World Health Organization, Avenue Appia 20, 1211 Geneva 27,  Switzerland.<br /><searchLink fieldCode="AU" term="%22Tomarevska+O%22">Tomarevska O</searchLink>; D.F. Chebotarev Institute of Gerontology of the National Academy of the Medical Sciences of Ukraine Kyiv, vulytsia Volodymyrska, 54 Kyiv City, Ukraine.<br /><searchLink fieldCode="AU" term="%22Vellas+B%22">Vellas B</searchLink>; IHU HealthAge, Gérontopôle de Toulouse, Centre Hospitalo-Universitaire de Toulouse, 2 Rue Viguerie, 31300, Toulouse, France.; CERPOP, UPS/Inserm 1295, 37 Allées Jules Guesde, 31400 Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Visvanathan+R%22">Visvanathan R</searchLink>; Adelaide Geriatrics Training and Research with Aged Care (GTRAC) Centre; School of Medicine, College of Health, Adelaide University, 4 North Terrace, Adelaide South Australia 5000, Australia.; Basil Hetzel Institute, Central Adelaide Local Health Network, 37A Woodville Rd, Adelaide South Australia 5011, Australia.<br /><searchLink fieldCode="AU" term="%22Woo+J%22">Woo J</searchLink>; Jockey Club Institute of Ageing, Suite 602, 6/F, Yasumoto International Academic Park, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Martin+FC%22">Martin FC</searchLink>; Faculty of Life Sciences & Medicine, Population Health Sciences, King's College London, Great Maze Pond, London SE1 9RT, UK.
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