Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models.
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| Title: | Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models. |
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| Authors: | Wang P; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; Department of Histology and Embryology, College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China.; Laboratory of Molecular Iron Metabolism, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Ministry of Education Key Laboratory of Molecular and Cellular Biology, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China., Du S; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Wu S; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Zhai Y; Division of Gastroenterology and Hepatology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China., Bai J; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; Laboratory of Molecular Iron Metabolism, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Ministry of Education Key Laboratory of Molecular and Cellular Biology, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China., Safdar A; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Liu Z; Division of Gastroenterology and Hepatology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China., Lu Z; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Li B; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China., Cheng J; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Song Y; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China., Zhang R; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100084, China., Li D; Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China., Wang Z; Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China., Zeng Z; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100084, China., Nie G; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Chang YZ; Laboratory of Molecular Iron Metabolism, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Ministry of Education Key Laboratory of Molecular and Cellular Biology, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China., Li S; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China. |
| Source: | Science translational medicine [Sci Transl Med] 2026 Jun 03; Vol. 18 (852), pp. eaea0189. Date of Electronic Publication: 2026 Jun 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42166543 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; Department of Histology and Embryology, College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China.; Laboratory of Molecular Iron Metabolism, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Ministry of Education Key Laboratory of Molecular and Cellular Biology, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China.<br /><searchLink fieldCode="AU" term="%22Du+S%22">Du S</searchLink>; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Zhai+Y%22">Zhai Y</searchLink>; Division of Gastroenterology and Hepatology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.<br /><searchLink fieldCode="AU" term="%22Bai+J%22">Bai J</searchLink>; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; Laboratory of Molecular Iron Metabolism, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Ministry of Education Key Laboratory of Molecular and Cellular Biology, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China.<br /><searchLink fieldCode="AU" term="%22Safdar+A%22">Safdar A</searchLink>; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Division of Gastroenterology and Hepatology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.<br /><searchLink fieldCode="AU" term="%22Lu+Z%22">Lu Z</searchLink>; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.<br /><searchLink fieldCode="AU" term="%22Cheng+J%22">Cheng J</searchLink>; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100084, China.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.<br /><searchLink fieldCode="AU" term="%22Zeng+Z%22">Zeng Z</searchLink>; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100084, China.<br /><searchLink fieldCode="AU" term="%22Nie+G%22">Nie G</searchLink>; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Chang+YZ%22">Chang YZ</searchLink>; Laboratory of Molecular Iron Metabolism, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Ministry of Education Key Laboratory of Molecular and Cellular Biology, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Jun 03; Vol. 18 (852), pp. eaea0189. <i>Date of Electronic Publication: </i>2026 Jun 03. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/scitranslmed.aea0189 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: eaea0189 Titles: – TitleFull: Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang P – PersonEntity: Name: NameFull: Du S – PersonEntity: Name: NameFull: Wu S – PersonEntity: Name: NameFull: Zhai Y – PersonEntity: Name: NameFull: Bai J – PersonEntity: Name: NameFull: Safdar A – PersonEntity: Name: NameFull: Liu Z – PersonEntity: Name: NameFull: Lu Z – PersonEntity: Name: NameFull: Li B – PersonEntity: Name: NameFull: Cheng J – PersonEntity: Name: NameFull: Song Y – PersonEntity: Name: NameFull: Zhang R – PersonEntity: Name: NameFull: Li D – PersonEntity: Name: NameFull: Wang Z – PersonEntity: Name: NameFull: Zeng Z – PersonEntity: Name: NameFull: Nie G – PersonEntity: Name: NameFull: Chang YZ – PersonEntity: Name: NameFull: Li S IsPartOfRelationships: – BibEntity: Dates: – D: 03 M: 06 Text: 2026 Jun 03 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1946-6242 Numbering: – Type: volume Value: 18 – Type: issue Value: 852 Titles: – TitleFull: Science translational medicine Type: main |
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