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The patient the trial cannot see: Clinical reasoning and mechanism in the age of precision medicine.

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Title: The patient the trial cannot see: Clinical reasoning and mechanism in the age of precision medicine.
Authors: Horwitz RI; Temple University, Philadelphia, PA, USA. Electronic address: horwitzri@gmail.com., Conroy AH; Temple University, Philadelphia, PA, USA., Cullen MR; Stanford University (Ret), Stanford, CA, USA., Sim I; UCSF, San Francisco, CA, USA.
Source: The American journal of medicine [Am J Med] 2026 May 20. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article; Review
Journal Info: Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0267200 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-7162 (Electronic) Linking ISSN: 00029343 NLM ISO Abbreviation: Am J Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Horwitz+RI%22">Horwitz RI</searchLink>; Temple University, Philadelphia, PA, USA. Electronic address: horwitzri@gmail.com.<br /><searchLink fieldCode="AU" term="%22Conroy+AH%22">Conroy AH</searchLink>; Temple University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cullen+MR%22">Cullen MR</searchLink>; Stanford University (Ret), Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sim+I%22">Sim I</searchLink>; UCSF, San Francisco, CA, USA.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Excerpta+Medica%22">Excerpta Medica </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0267200 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1555-7162 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200029343%22">00029343 </searchLink><i>NLM ISO Abbreviation: </i>Am J Med <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.amjmed.2026.05.008
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        Text: English
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              Text: 2026 May 20
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