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TP53 mutations in triple-negative breast cancer cells confer sensitivity to ASCT2 inhibition via arginine uptake.

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Title: TP53 mutations in triple-negative breast cancer cells confer sensitivity to ASCT2 inhibition via arginine uptake.
Authors: Lyu X; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China., Wei Y; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China., Chen Z; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China., Zou Q; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China., Wang J; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China., Han Y; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China., Xu C; Laney Graduate School, Emory University, Atlanta, GA, USA., Hu H; General Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China., Zhou Z; State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, China., Yuan S; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China. yuanst1967@163.com., Yang M; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China. yangmei@cpu.edu.cn., Sun L; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China. sunli@cpu.edu.cn.
Source: Cell death & disease [Cell Death Dis] 2026 May 21; Vol. 17 (1). Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TP53 mutations in triple-negative breast cancer cells confer sensitivity to ASCT2 inhibition via arginine uptake.
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  Data: <searchLink fieldCode="AU" term="%22Lyu+X%22">Lyu X</searchLink>; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wei+Y%22">Wei Y</searchLink>; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zou+Q%22">Zou Q</searchLink>; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Han+Y%22">Han Y</searchLink>; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Laney Graduate School, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; General Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, China.<br /><searchLink fieldCode="AU" term="%22Yuan+S%22">Yuan S</searchLink>; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China. yuanst1967@163.com.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China. yangmei@cpu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Sun+L%22">Sun L</searchLink>; New Drug Screening and Pharmacodynamics Evaluation Center, National Key Laboratory for Multi-Target Natural Drugs, China Pharmaceutical University, Nanjing, China. sunli@cpu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 May 21; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42168145
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        Value: 10.1038/s41419-026-08814-x
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              Text: 2026 May 21
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