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Molecular basis of allosteric regulation and pharmaceutical targeting of protein kinase Cβ.

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Title: Molecular basis of allosteric regulation and pharmaceutical targeting of protein kinase Cβ.
Authors: Cong ATQ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Witter TL; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Bruinsma ES; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Sarkar Bhattacharya S; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Jayaraman S; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Wyatt SR; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Solverson JK; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Dugan MB; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Paluncic J; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Kuffel MJ; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Alvey JR; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Huynh HV; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Wu X; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Fields AP; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA., Pandey A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Manipal Academy of Higher Education, Manipal, India., Hawse JR; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Goetz MP; Department of Oncology, Mayo Clinic, Rochester, MN, USA. goetz.matthew@mayo.edu.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. goetz.matthew@mayo.edu., Schellenberg MJ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. schellenberg.matthew@mayo.edu.
Source: Nature communications [Nat Commun] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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