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Co-occurring clonal hematopoiesis exhibits strong selection and high leukemia risk.

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Title: Co-occurring clonal hematopoiesis exhibits strong selection and high leukemia risk.
Authors: Barnao KM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA. kara.barnao@nih.gov., Hubbard AK; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Chan ICC; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Zhou W; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, USA., Jakubek YA; Department of Internal Medicine, University of Kentucky, Lexington, KY, USA., Genovese G; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wong WSW; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Kelly RL; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Young CD; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Brown DW; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Huang WY; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Freedman ND; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Jones K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, USA., Hutchinson A; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, USA., Hicks B; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, USA., Tran D; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Arnett D; University of South Carolina, Columbia, SC, USA., Barnes KC; Galatea Bio, Inc., Miami, FL, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Boerwinkle E; Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Carson AP; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Chasman DI; Harvard Medical School, Boston, MA, USA.; Division of Preventative Medicine, Brigham and Women's Hospital, Boston, MA, USA., Cho MH; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA., Desai P; Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY, USA., Doyle MF; Department of Pathology and Laboratory Medicine, The University of Vermont Lerner College of Medicine, Colchester, VT, USA., Fornage M; Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA., Guo X; Department of Medicine, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Heard-Costa N; Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Johnson AD; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kooperberg C; Division of Public Health Science, Fred Hutchinson Cancer Center, Seattle, WA, USA., Levy D; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Lewis JP; Department of Medicine, University of Maryland Baltimore, Baltimore, MD, USA., Li Y; Department of Genetics, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mack TM; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Mathias RA; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Mitchell BD; Department of Medicine, University of Maryland Baltimore, Baltimore, MD, USA., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Pankratz N; Depart of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Redline S; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Rich SS; Department of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Silverman EK; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA., Smith AV; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Stilp A; Department of Biostatistics, University of Washington, Seattle, WA, USA., Cao Y; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Scheet P; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA., Bick AG; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Auer PL; Division of Biostatistics, Data Science Institute, and Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA., Bolton KL; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA. mitchell.machiela@nih.gov.
Source: Nature communications [Nat Commun] 2026 May 21; Vol. 17 (1). Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Co-occurring clonal hematopoiesis exhibits strong selection and high leukemia risk.
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          Name:
            NameFull: Psaty BM
      – PersonEntity:
          Name:
            NameFull: Raffield LM
      – PersonEntity:
          Name:
            NameFull: Redline S
      – PersonEntity:
          Name:
            NameFull: Rich SS
      – PersonEntity:
          Name:
            NameFull: Rotter JI
      – PersonEntity:
          Name:
            NameFull: Silverman EK
      – PersonEntity:
          Name:
            NameFull: Smith AV
      – PersonEntity:
          Name:
            NameFull: Smith JA
      – PersonEntity:
          Name:
            NameFull: Stilp A
      – PersonEntity:
          Name:
            NameFull: Cao Y
      – PersonEntity:
          Name:
            NameFull: Scheet P
      – PersonEntity:
          Name:
            NameFull: Reiner AP
      – PersonEntity:
          Name:
            NameFull: Bick AG
      – PersonEntity:
          Name:
            NameFull: Chanock SJ
      – PersonEntity:
          Name:
            NameFull: Auer PL
      – PersonEntity:
          Name:
            NameFull: Bolton KL
      – PersonEntity:
          Name:
            NameFull: Machiela MJ
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 21
              M: 05
              Text: 2026 May 21
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1