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De novo design of miniproteins targeting GPCRs.

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Title: De novo design of miniproteins targeting GPCRs.
Authors: Muratspahić E; Department of Biochemistry, University of Washington, Seattle, WA, USA. edinm2@uw.edu.; Institute for Protein Design, University of Washington, Seattle, WA, USA. edinm2@uw.edu., Feldman D; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; BioInnovation Institute, Copenhagen, Denmark., Kim DE; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Qu X; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Bratovianu AM; BioInnovation Institute, Copenhagen, Denmark.; Skape Bio, Copenhagen, Denmark., Rivera-Sánchez P; BioInnovation Institute, Copenhagen, Denmark.; Skape Bio, Copenhagen, Denmark., Voss JH; Skape Bio, Copenhagen, Denmark., Hertz EPT; Skape Bio, Copenhagen, Denmark., Jeppesen M; Skape Bio, Copenhagen, Denmark., Dimitri F; BioInnovation Institute, Copenhagen, Denmark., Sakamoto K; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; NIMH Psychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Nallathambi A; Skape Bio, Copenhagen, Denmark., Peceli P; Skape Bio, Copenhagen, Denmark., Cao J; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Cary BP; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Belousoff MJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Keov P; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Trinh PNH; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Chen Q; MRC Laboratory of Molecular Biology, Cambridge, UK., Ren Y; MRC Laboratory of Molecular Biology, Cambridge, UK., Fine J; Program in Molecular Biophysics, Johns Hopkins University, Baltimore, MD, USA.; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA., Mishra S; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India., Dalal A; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India., Sinha S; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India., Banerjee R; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India., Ganguly M; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India., Karuppusamy KV; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA., Sappington I; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Schlichthaerle T; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Zhang JZ; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Pillai A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Coventry B; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Mihaljević L; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Bauer MS; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Torres SV; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Motmaen A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Lee GR; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Tran L; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Chemical Engineering, University of Washington, Seattle, WA, USA., Wang X; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Goreshnik I; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Vafeados DK; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Svendsen JE; Department of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.; Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR, USA., Hosseinzadeh P; Department of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.; Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR, USA., Lindegaard N; Novo Nordisk, Måløv, Denmark., Brandt M; Novo Nordisk, Måløv, Denmark., Waltenspühl Y; Novo Nordisk, Måløv, Denmark., Deibler K; Novo Nordisk, Måløv, Denmark., Deweid L; Novo Nordisk, Måløv, Denmark., Bennett A; Novo Nordisk, Måløv, Denmark., Schöppe J; Novo Nordisk, Måløv, Denmark., Dong T; Novo Nordisk Research Centre China, Beijing, China., Yan X; Novo Nordisk Research Centre China, Beijing, China., Oostdyk L; LeadHunter Services, Eurofins DiscoverX, Fremont, CA, USA., Cao W; LeadHunter Services, Eurofins DiscoverX, Fremont, CA, USA., Anantharaman L; LeadHunter Services, Eurofins DiscoverX, Fremont, CA, USA., Weisser JJ; Global Research, H. Lundbeck, Copenhagen, Denmark., Bastlund JF; Global Research, H. Lundbeck, Copenhagen, Denmark., Bundgaard C; Global Research, H. Lundbeck, Copenhagen, Denmark., Asuni AA; Global Research, H. Lundbeck, Copenhagen, Denmark., English JG; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Stewart LJ; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Halloran L; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Spangler JB; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Lieber A; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA., Shukla AK; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India., Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Roth BL; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; NIMH Psychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Krumm BE; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; NIMH Psychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wootten D; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Tate CG; MRC Laboratory of Molecular Biology, Cambridge, UK., Norn C; Department of Biochemistry, University of Washington, Seattle, WA, USA. chris.norn@skape.bio.; Institute for Protein Design, University of Washington, Seattle, WA, USA. chris.norn@skape.bio.; BioInnovation Institute, Copenhagen, Denmark. chris.norn@skape.bio.; Skape Bio, Copenhagen, Denmark. chris.norn@skape.bio., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
Source: Nature [Nature] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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DbLabel: MEDLINE Ultimate
An: 42168559
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: De novo design of miniproteins targeting GPCRs.
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  Data: <searchLink fieldCode="AU" term="%22Muratspahić+E%22">Muratspahić E</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA. edinm2@uw.edu.; Institute for Protein Design, University of Washington, Seattle, WA, USA. edinm2@uw.edu.<br /><searchLink fieldCode="AU" term="%22Feldman+D%22">Feldman D</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; BioInnovation Institute, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kim+DE%22">Kim DE</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Qu+X%22">Qu X</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bratovianu+AM%22">Bratovianu AM</searchLink>; BioInnovation Institute, Copenhagen, Denmark.; Skape Bio, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rivera-Sánchez+P%22">Rivera-Sánchez P</searchLink>; BioInnovation Institute, Copenhagen, Denmark.; Skape Bio, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Voss+JH%22">Voss JH</searchLink>; Skape Bio, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hertz+EPT%22">Hertz EPT</searchLink>; Skape Bio, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jeppesen+M%22">Jeppesen M</searchLink>; Skape Bio, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Dimitri+F%22">Dimitri F</searchLink>; BioInnovation Institute, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sakamoto+K%22">Sakamoto K</searchLink>; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; NIMH Psychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Nallathambi+A%22">Nallathambi A</searchLink>; 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ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Keov+P%22">Keov P</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Trinh+PNH%22">Trinh PNH</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; MRC Laboratory of Molecular Biology, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ren+Y%22">Ren Y</searchLink>; 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Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.<br /><searchLink fieldCode="AU" term="%22Karuppusamy+KV%22">Karuppusamy KV</searchLink>; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Sappington+I%22">Sappington I</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Schlichthaerle+T%22">Schlichthaerle T</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+JZ%22">Zhang JZ</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Pillai+A%22">Pillai A</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Coventry+B%22">Coventry B</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mihaljević+L%22">Mihaljević L</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bauer+MS%22">Bauer MS</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Torres+SV%22">Torres SV</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; 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Novo Nordisk, Måløv, Denmark.<br /><searchLink fieldCode="AU" term="%22Brandt+M%22">Brandt M</searchLink>; Novo Nordisk, Måløv, Denmark.<br /><searchLink fieldCode="AU" term="%22Waltenspühl+Y%22">Waltenspühl Y</searchLink>; Novo Nordisk, Måløv, Denmark.<br /><searchLink fieldCode="AU" term="%22Deibler+K%22">Deibler K</searchLink>; Novo Nordisk, Måløv, Denmark.<br /><searchLink fieldCode="AU" term="%22Deweid+L%22">Deweid L</searchLink>; Novo Nordisk, Måløv, Denmark.<br /><searchLink fieldCode="AU" term="%22Bennett+A%22">Bennett A</searchLink>; Novo Nordisk, Måløv, Denmark.<br /><searchLink fieldCode="AU" term="%22Schöppe+J%22">Schöppe J</searchLink>; Novo Nordisk, Måløv, Denmark.<br /><searchLink fieldCode="AU" term="%22Dong+T%22">Dong T</searchLink>; Novo Nordisk Research Centre China, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yan+X%22">Yan X</searchLink>; Novo Nordisk Research Centre China, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Oostdyk+L%22">Oostdyk L</searchLink>; 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Lundbeck, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22English+JG%22">English JG</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Stewart+LJ%22">Stewart LJ</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Halloran+L%22">Halloran L</searchLink>; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Spangler+JB%22">Spangler JB</searchLink>; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lieber+A%22">Lieber A</searchLink>; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Shukla+AK%22">Shukla AK</searchLink>; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.<br /><searchLink fieldCode="AU" term="%22Sexton+PM%22">Sexton PM</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Roth+BL%22">Roth BL</searchLink>; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; NIMH Psychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Krumm+BE%22">Krumm BE</searchLink>; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; NIMH Psychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Wootten+D%22">Wootten D</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Tate+CG%22">Tate CG</searchLink>; MRC Laboratory of Molecular Biology, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Norn+C%22">Norn C</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA. chris.norn@skape.bio.; Institute for Protein Design, University of Washington, Seattle, WA, USA. chris.norn@skape.bio.; BioInnovation Institute, Copenhagen, Denmark. chris.norn@skape.bio.; Skape Bio, Copenhagen, Denmark. chris.norn@skape.bio.<br /><searchLink fieldCode="AU" term="%22Baker+D%22">Baker D</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
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          Dates:
            – D: 21
              M: 05
              Text: 2026 May 21
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1