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Empagliflozin restores cardiac function in obese-diabetic HFpEF mice but further alters gene expression.

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Title: Empagliflozin restores cardiac function in obese-diabetic HFpEF mice but further alters gene expression.
Authors: Mira Hernandez J; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.; Research Group Biogenesis, Faculty of Agricultural Sciences, Veterinary Medicine, University of Antioquia, Medellin, Colombia., Bailey LRJ; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.; Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA., Salemme VR; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA., Ko CY; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA., Shen EY; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA., Ngim M; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA., Hoang DT; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA., Corea M; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA., Bossuyt J; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA., Davis JM; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.; Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA., Bers DM; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA. dmbers@ucdavis.edu., Hegyi B; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA. bhegyi@ucdavis.edu.
Source: Basic research in cardiology [Basic Res Cardiol] 2026 Aug; Vol. 121 (4), pp. 669-688. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Steinkopff Country of Publication: Germany NLM ID: 0360342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-1803 (Electronic) Linking ISSN: 03008428 NLM ISO Abbreviation: Basic Res Cardiol Subsets: MEDLINE
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  Data: Empagliflozin restores cardiac function in obese-diabetic HFpEF mice but further alters gene expression.
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  Data: <searchLink fieldCode="AU" term="%22Mira+Hernandez+J%22">Mira Hernandez J</searchLink>; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.; Research Group Biogenesis, Faculty of Agricultural Sciences, Veterinary Medicine, University of Antioquia, Medellin, Colombia.<br /><searchLink fieldCode="AU" term="%22Bailey+LRJ%22">Bailey LRJ</searchLink>; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.; Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Salemme+VR%22">Salemme VR</searchLink>; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.<br /><searchLink fieldCode="AU" term="%22Ko+CY%22">Ko CY</searchLink>; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.<br /><searchLink fieldCode="AU" term="%22Shen+EY%22">Shen EY</searchLink>; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.<br /><searchLink fieldCode="AU" term="%22Ngim+M%22">Ngim M</searchLink>; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.<br /><searchLink fieldCode="AU" term="%22Hoang+DT%22">Hoang DT</searchLink>; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.<br /><searchLink fieldCode="AU" term="%22Corea+M%22">Corea M</searchLink>; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.<br /><searchLink fieldCode="AU" term="%22Bossuyt+J%22">Bossuyt J</searchLink>; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA.<br /><searchLink fieldCode="AU" term="%22Davis+JM%22">Davis JM</searchLink>; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.; Department of Lab Medicine and Pathology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bers+DM%22">Bers DM</searchLink>; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA. dmbers@ucdavis.edu.<br /><searchLink fieldCode="AU" term="%22Hegyi+B%22">Hegyi B</searchLink>; Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, Davis, CA, 95616, USA. bhegyi@ucdavis.edu.
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  Data: <searchLink fieldCode="JN" term="%220360342%22">Basic research in cardiology</searchLink> [Basic Res Cardiol] 2026 Aug; Vol. 121 (4), pp. 669-688. <i>Date of Electronic Publication: </i>2026 May 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Steinkopff%22">Steinkopff </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0360342 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1435-1803 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203008428%22">03008428 </searchLink><i>NLM ISO Abbreviation: </i>Basic Res Cardiol <i>Subsets: </i>MEDLINE
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