Effect of somatostatin receptor 2 antagonism on glucagon counterregulation during a hyperinsulinaemic euglycaemic-hypoglycaemic glucose clamp in adult men and women with long-standing type 1 diabetes: a randomised crossover phase 1 study.
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| Title: | Effect of somatostatin receptor 2 antagonism on glucagon counterregulation during a hyperinsulinaemic euglycaemic-hypoglycaemic glucose clamp in adult men and women with long-standing type 1 diabetes: a randomised crossover phase 1 study. |
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| Authors: | Abitbol A; LMC Diabetes & Endocrinology, Toronto, ON, Canada.; Centricity Research, Toronto, ON, Canada., Riddell MC; LMC Diabetes & Endocrinology, Toronto, ON, Canada.; Muscle Health Research Centre, York University, Toronto, ON, Canada., Peers S; Zucara Therapeutics Inc., Toronto, ON, Canada., Simonson E; Zucara Therapeutics Inc., Vancouver, BC, Canada., Evans M; Institute of Metabolic Science and Department of Medicine, University of Cambridge, Cambridge, UK., Knop FK; Center for Clinical Metabolic Research, Copenhagen University Hospital - Herlev and Gentofte, Hellerup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Liggins RT; Zucara Therapeutics Inc., Vancouver, BC, Canada. rliggins@zucara.ca. |
| Source: | Diabetologia [Diabetologia] 2026 Aug; Vol. 69 (8), pp. 2143-2154. Date of Electronic Publication: 2026 May 21. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42168649 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effect of somatostatin receptor 2 antagonism on glucagon counterregulation during a hyperinsulinaemic euglycaemic-hypoglycaemic glucose clamp in adult men and women with long-standing type 1 diabetes: a randomised crossover phase 1 study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Abitbol+A%22">Abitbol A</searchLink>; LMC Diabetes & Endocrinology, Toronto, ON, Canada.; Centricity Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Riddell+MC%22">Riddell MC</searchLink>; LMC Diabetes & Endocrinology, Toronto, ON, Canada.; Muscle Health Research Centre, York University, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Peers+S%22">Peers S</searchLink>; Zucara Therapeutics Inc., Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Simonson+E%22">Simonson E</searchLink>; Zucara Therapeutics Inc., Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Evans+M%22">Evans M</searchLink>; Institute of Metabolic Science and Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Knop+FK%22">Knop FK</searchLink>; Center for Clinical Metabolic Research, Copenhagen University Hospital - Herlev and Gentofte, Hellerup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Liggins+RT%22">Liggins RT</searchLink>; Zucara Therapeutics Inc., Vancouver, BC, Canada. rliggins@zucara.ca. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220006777%22">Diabetologia</searchLink> [Diabetologia] 2026 Aug; Vol. 69 (8), pp. 2143-2154. <i>Date of Electronic Publication: </i>2026 May 21. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0006777 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0428 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220012186X%22">0012186X </searchLink><i>NLM ISO Abbreviation: </i>Diabetologia <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42168649 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00125-026-06748-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2143 Titles: – TitleFull: Effect of somatostatin receptor 2 antagonism on glucagon counterregulation during a hyperinsulinaemic euglycaemic-hypoglycaemic glucose clamp in adult men and women with long-standing type 1 diabetes: a randomised crossover phase 1 study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Abitbol A – PersonEntity: Name: NameFull: Riddell MC – PersonEntity: Name: NameFull: Peers S – PersonEntity: Name: NameFull: Simonson E – PersonEntity: Name: NameFull: Evans M – PersonEntity: Name: NameFull: Knop FK – PersonEntity: Name: NameFull: Liggins RT IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2026 Aug Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1432-0428 Numbering: – Type: volume Value: 69 – Type: issue Value: 8 Titles: – TitleFull: Diabetologia Type: main |
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