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Impact of an online-guided physical activity intervention on cognition, resting-state brain connectivity, and the gut microbiome in healthy older adults-a randomized controlled trial.

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Title: Impact of an online-guided physical activity intervention on cognition, resting-state brain connectivity, and the gut microbiome in healthy older adults-a randomized controlled trial.
Authors: Schrenk SJ; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany. simon.schrenk@med.uni-jena.de., Bang C; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Straße 12, Kiel, 24105, Germany., Best L; Institute for Experimental Medicine, Kiel University, Michaelisstraße 5, Kiel, 24105, Germany., Dost T; Institute for Experimental Medicine, Kiel University, Michaelisstraße 5, Kiel, 24105, Germany., Flor S; Institute for Experimental Medicine, Kiel University, Michaelisstraße 5, Kiel, 24105, Germany., Frahm C; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany., Gaser C; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.; Department of Psychiatry and Psychotherapy, Jena University Hospital - Friedrich Schiller University of Jena, Philosophenweg 3, Jena, 07747, Germany., Hamdan RA; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Wöllnitzer Straße 42, Jena, 07749, Germany., Herbsleb M; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Wöllnitzer Straße 42, Jena, 07749, Germany.; Department of Psychosomatic Medicine and Psychotherapy, Jena University Hospital - Friedrich Schiller University of Jena, Philosophenweg 3, Jena, 07743, Germany., Kaleta C; Institute for Experimental Medicine, Kiel University, Michaelisstraße 5, Kiel, 24105, Germany., Kattlun F; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany., Müller HJ; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Wöllnitzer Straße 42, Jena, 07749, Germany., Puta C; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Wöllnitzer Straße 42, Jena, 07749, Germany.; Center for Sepsis Control and Care (CSCC), Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.; Center for Interdisciplinary Prevention of Diseases Related to Professional Activities, Friedrich-Schiller-University Jena, Wöllnitzer Straße 42, Jena, 07749, Germany., Radscheidt M; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany., Ruiz-Rizzo AL; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany., Scherag A; Center for Sepsis Control and Care (CSCC), Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.; Center for Clinical Studies, Jena University Hospital - Friedrich Schiller University of Jena, Salvador-Allende-Platz 27, Jena, 07747, Germany.; Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital - Friedrich Schiller University of Jena, Bachstraße 18, Jena, 07743, Germany., Steidten T; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Wöllnitzer Straße 42, Jena, 07749, Germany., Witte OW; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany., Brodoehl S; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany., Finke K; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.; Center for Sepsis Control and Care (CSCC), Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.
Source: GeroScience [Geroscience] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Impact of an online-guided physical activity intervention on cognition, resting-state brain connectivity, and the gut microbiome in healthy older adults-a randomized controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Schrenk+SJ%22">Schrenk SJ</searchLink>; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany. simon.schrenk@med.uni-jena.de.<br /><searchLink fieldCode="AU" term="%22Bang+C%22">Bang C</searchLink>; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Straße 12, Kiel, 24105, Germany.<br /><searchLink fieldCode="AU" term="%22Best+L%22">Best L</searchLink>; Institute for Experimental Medicine, Kiel University, Michaelisstraße 5, Kiel, 24105, Germany.<br /><searchLink fieldCode="AU" term="%22Dost+T%22">Dost T</searchLink>; Institute for Experimental Medicine, Kiel University, Michaelisstraße 5, Kiel, 24105, Germany.<br /><searchLink fieldCode="AU" term="%22Flor+S%22">Flor S</searchLink>; Institute for Experimental Medicine, Kiel University, Michaelisstraße 5, Kiel, 24105, Germany.<br /><searchLink fieldCode="AU" term="%22Frahm+C%22">Frahm C</searchLink>; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.<br /><searchLink fieldCode="AU" term="%22Gaser+C%22">Gaser C</searchLink>; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.; Department of Psychiatry and Psychotherapy, Jena University Hospital - Friedrich Schiller University of Jena, Philosophenweg 3, Jena, 07747, Germany.<br /><searchLink fieldCode="AU" term="%22Hamdan+RA%22">Hamdan RA</searchLink>; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Wöllnitzer Straße 42, Jena, 07749, Germany.<br /><searchLink fieldCode="AU" term="%22Herbsleb+M%22">Herbsleb M</searchLink>; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Wöllnitzer Straße 42, Jena, 07749, Germany.; Department of Psychosomatic Medicine and Psychotherapy, Jena University Hospital - Friedrich Schiller University of Jena, Philosophenweg 3, Jena, 07743, Germany.<br /><searchLink fieldCode="AU" term="%22Kaleta+C%22">Kaleta C</searchLink>; Institute for Experimental Medicine, Kiel University, Michaelisstraße 5, Kiel, 24105, Germany.<br /><searchLink fieldCode="AU" term="%22Kattlun+F%22">Kattlun F</searchLink>; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+HJ%22">Müller HJ</searchLink>; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Wöllnitzer Straße 42, Jena, 07749, Germany.<br /><searchLink fieldCode="AU" term="%22Puta+C%22">Puta C</searchLink>; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Wöllnitzer Straße 42, Jena, 07749, Germany.; Center for Sepsis Control and Care (CSCC), Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.; Center for Interdisciplinary Prevention of Diseases Related to Professional Activities, Friedrich-Schiller-University Jena, Wöllnitzer Straße 42, Jena, 07749, Germany.<br /><searchLink fieldCode="AU" term="%22Radscheidt+M%22">Radscheidt M</searchLink>; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.<br /><searchLink fieldCode="AU" term="%22Ruiz-Rizzo+AL%22">Ruiz-Rizzo AL</searchLink>; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.<br /><searchLink fieldCode="AU" term="%22Scherag+A%22">Scherag A</searchLink>; Center for Sepsis Control and Care (CSCC), Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.; Center for Clinical Studies, Jena University Hospital - Friedrich Schiller University of Jena, Salvador-Allende-Platz 27, Jena, 07747, Germany.; Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital - Friedrich Schiller University of Jena, Bachstraße 18, Jena, 07743, Germany.<br /><searchLink fieldCode="AU" term="%22Steidten+T%22">Steidten T</searchLink>; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Wöllnitzer Straße 42, Jena, 07749, Germany.<br /><searchLink fieldCode="AU" term="%22Witte+OW%22">Witte OW</searchLink>; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.<br /><searchLink fieldCode="AU" term="%22Brodoehl+S%22">Brodoehl S</searchLink>; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.<br /><searchLink fieldCode="AU" term="%22Finke+K%22">Finke K</searchLink>; Department of Neurology, Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.; Center for Sepsis Control and Care (CSCC), Jena University Hospital - Friedrich Schiller University of Jena, Am Klinikum 1, Jena, 07747, Germany.
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