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Checkpoint kinase 2 coordinates autophagy activation and Aurora kinase A degradation to regulate primary cilia for cell invasion.

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Title: Checkpoint kinase 2 coordinates autophagy activation and Aurora kinase A degradation to regulate primary cilia for cell invasion.
Authors: Wang CY; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan. b89609046@gmail.com.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan. b89609046@gmail.com., Chao YY; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan., Chen TY; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan., Lin RC; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan., Tsai HM; Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan.; National Center for Biomodels, National Institutes of Applied Research, Taipei, 115, Taiwan., Huang HH; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 701, Taiwan., Chen ZR; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 701, Taiwan., Lu FI; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 701, Taiwan.; The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, 402, Taiwan., Su YC; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan., Chung BC; Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan. mbchung@sinica.edu.tw.; National Center for Biomodels, National Institutes of Applied Research, Taipei, 115, Taiwan. mbchung@sinica.edu.tw.; Graduate Institute of Biomedical Sciences, Neuroscience and Brain Disease Center, China Medical University, Taichung, 404, Taiwan. mbchung@sinica.edu.tw.
Source: Cell communication and signaling : CCS [Cell Commun Signal] 2026 May 22; Vol. 24 (1). Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Checkpoint kinase 2 coordinates autophagy activation and Aurora kinase A degradation to regulate primary cilia for cell invasion.
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  Data: <searchLink fieldCode="AU" term="%22Wang+CY%22">Wang CY</searchLink>; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan. b89609046@gmail.com.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan. b89609046@gmail.com.<br /><searchLink fieldCode="AU" term="%22Chao+YY%22">Chao YY</searchLink>; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+TY%22">Chen TY</searchLink>; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+RC%22">Lin RC</searchLink>; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+HM%22">Tsai HM</searchLink>; Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan.; National Center for Biomodels, National Institutes of Applied Research, Taipei, 115, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+HH%22">Huang HH</searchLink>; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 701, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+ZR%22">Chen ZR</searchLink>; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 701, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+FI%22">Lu FI</searchLink>; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 701, Taiwan.; The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, 402, Taiwan.<br /><searchLink fieldCode="AU" term="%22Su+YC%22">Su YC</searchLink>; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chung+BC%22">Chung BC</searchLink>; Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan. mbchung@sinica.edu.tw.; National Center for Biomodels, National Institutes of Applied Research, Taipei, 115, Taiwan. mbchung@sinica.edu.tw.; Graduate Institute of Biomedical Sciences, Neuroscience and Brain Disease Center, China Medical University, Taichung, 404, Taiwan. mbchung@sinica.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101170464%22">Cell communication and signaling : CCS</searchLink> [Cell Commun Signal] 2026 May 22; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 May 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101170464 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1478-811X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221478811X%22">1478811X </searchLink><i>NLM ISO Abbreviation: </i>Cell Commun Signal <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42169006
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      – Type: doi
        Value: 10.1186/s12964-026-02953-6
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        Text: English
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      – TitleFull: Checkpoint kinase 2 coordinates autophagy activation and Aurora kinase A degradation to regulate primary cilia for cell invasion.
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              M: 05
              Text: 2026 May 22
              Type: published
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