View in EDS

Proteolysis-targeting chimera (PROTAC) in cancer: design principles and applications on "undruggable" targets.

Saved in:
Bibliographic Details
Title: Proteolysis-targeting chimera (PROTAC) in cancer: design principles and applications on "undruggable" targets.
Authors: Lu X; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China., Qin J; State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, China., Dong S; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China., Yuan Y; Division of Gastroenterology, Department of Internal Medicine at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zhang Z; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China., Zhang B; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China., Chen X; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China., Gan X; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China. lililovebox@126.com.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China. lililovebox@126.com.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China. lililovebox@126.com., Liang H; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China. lianghuifang1997@126.com.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China. lianghuifang1997@126.com.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China. lianghuifang1997@126.com., Liu F; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China. furongliu@hust.edu.cn.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China. furongliu@hust.edu.cn.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China. furongliu@hust.edu.cn.
Source: Biomarker research [Biomark Res] 2026 May 21; Vol. 14 (1). Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101607860 Publication Model: Electronic Cited Medium: Print ISSN: 2050-7771 (Print) Linking ISSN: 20507771 NLM ISO Abbreviation: Biomark Res Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42169196
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Proteolysis-targeting chimera (PROTAC) in cancer: design principles and applications on "undruggable" targets.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Qin+J%22">Qin J</searchLink>; State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Dong+S%22">Dong S</searchLink>; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Yuan+Y%22">Yuan Y</searchLink>; Division of Gastroenterology, Department of Internal Medicine at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Gan+X%22">Gan X</searchLink>; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China. lililovebox@126.com.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China. lililovebox@126.com.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China. lililovebox@126.com.<br /><searchLink fieldCode="AU" term="%22Liang+H%22">Liang H</searchLink>; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China. lianghuifang1997@126.com.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China. lianghuifang1997@126.com.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China. lianghuifang1997@126.com.<br /><searchLink fieldCode="AU" term="%22Liu+F%22">Liu F</searchLink>; Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, China. furongliu@hust.edu.cn.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, China. furongliu@hust.edu.cn.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China. furongliu@hust.edu.cn.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101607860%22">Biomarker research</searchLink> [Biomark Res] 2026 May 21; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 May 21.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Review
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101607860 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2050-7771 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220507771%22">20507771 </searchLink><i>NLM ISO Abbreviation: </i>Biomark Res <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42169196
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1186/s40364-026-00937-9
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Proteolysis-targeting chimera (PROTAC) in cancer: design principles and applications on "undruggable" targets.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Lu X
      – PersonEntity:
          Name:
            NameFull: Qin J
      – PersonEntity:
          Name:
            NameFull: Dong S
      – PersonEntity:
          Name:
            NameFull: Yuan Y
      – PersonEntity:
          Name:
            NameFull: Zhang Z
      – PersonEntity:
          Name:
            NameFull: Zhang B
      – PersonEntity:
          Name:
            NameFull: Chen X
      – PersonEntity:
          Name:
            NameFull: Gan X
      – PersonEntity:
          Name:
            NameFull: Liang H
      – PersonEntity:
          Name:
            NameFull: Liu F
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 21
              M: 05
              Text: 2026 May 21
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 2050-7771
          Numbering:
            – Type: volume
              Value: 14
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Biomarker research
              Type: main
ResultId 1