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Deleterious in vitro effects of ammonia and accumulated urea cycle amino acids on leukocyte DNA: assessment of the antioxidant effects of N-acetylcysteine and L-carnitine.

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Title: Deleterious in vitro effects of ammonia and accumulated urea cycle amino acids on leukocyte DNA: assessment of the antioxidant effects of N-acetylcysteine and L-carnitine.
Authors: Lopes FF; Programa de Pós-Graduação Em Ciências Farmacêuticas, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil. franciele.f.lopes@gmail.com.; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil. franciele.f.lopes@gmail.com.; Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil. franciele.f.lopes@gmail.com., Faverzani JL; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil., Dos Reis BG; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil., Böttcher AK; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil., Tedesco LMB; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil.; Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil., Altenhofen S; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil., Dos Santos LS; Universidade Federal Do Pampa (UNIPAMPA), Campus Uruguaiana, Uruguaiana, Brazil., Schreiner GE; Universidade Federal Do Pampa (UNIPAMPA), Campus Uruguaiana, Uruguaiana, Brazil., Manfredini V; Universidade Federal Do Pampa (UNIPAMPA), Campus Uruguaiana, Uruguaiana, Brazil., Wajner M; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil., Vargas CR; Programa de Pós-Graduação Em Ciências Farmacêuticas, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil. crvargas@hcpa.edu.br.; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil. crvargas@hcpa.edu.br.; Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil. crvargas@hcpa.edu.br.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 May 22. Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lopes+FF%22">Lopes FF</searchLink>; Programa de Pós-Graduação Em Ciências Farmacêuticas, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil. franciele.f.lopes@gmail.com.; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil. franciele.f.lopes@gmail.com.; Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil. franciele.f.lopes@gmail.com.<br /><searchLink fieldCode="AU" term="%22Faverzani+JL%22">Faverzani JL</searchLink>; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Reis+BG%22">Dos Reis BG</searchLink>; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil.<br /><searchLink fieldCode="AU" term="%22Böttcher+AK%22">Böttcher AK</searchLink>; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil.<br /><searchLink fieldCode="AU" term="%22Tedesco+LMB%22">Tedesco LMB</searchLink>; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil.; Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Altenhofen+S%22">Altenhofen S</searchLink>; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+LS%22">Dos Santos LS</searchLink>; Universidade Federal Do Pampa (UNIPAMPA), Campus Uruguaiana, Uruguaiana, Brazil.<br /><searchLink fieldCode="AU" term="%22Schreiner+GE%22">Schreiner GE</searchLink>; Universidade Federal Do Pampa (UNIPAMPA), Campus Uruguaiana, Uruguaiana, Brazil.<br /><searchLink fieldCode="AU" term="%22Manfredini+V%22">Manfredini V</searchLink>; Universidade Federal Do Pampa (UNIPAMPA), Campus Uruguaiana, Uruguaiana, Brazil.<br /><searchLink fieldCode="AU" term="%22Wajner+M%22">Wajner M</searchLink>; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil.<br /><searchLink fieldCode="AU" term="%22Vargas+CR%22">Vargas CR</searchLink>; Programa de Pós-Graduação Em Ciências Farmacêuticas, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil. crvargas@hcpa.edu.br.; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, Porto Alegre, RS, CEP, 2350, Brazil. crvargas@hcpa.edu.br.; Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil. crvargas@hcpa.edu.br.
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