Central nervous system and leptomeningeal metastases in patients with HER2-positive breast cancer: A comprehensive review and therapeutic algorithm proposal.

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Title: Central nervous system and leptomeningeal metastases in patients with HER2-positive breast cancer: A comprehensive review and therapeutic algorithm proposal.
Authors: Caltavituro A; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain., Buonaiuto R; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy., Longobardi A; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy., Trasacco P; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy., Martinelli C; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy., Grazia GD; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain., Pacelli R; Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy., Arpino G; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy., Angelis C; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy., Caputo R; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy., Laurentiis M; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy., Laakmann E; University Medical Center Hamburg-Eppendorf, Department of Gynecology, Hamburg, Germany., de Matos LV; Breast Cancer Unit, Champalimaud Clinical Centre, Champalimaud Foundation, Lisbon, Portugal., Fontes-Sousa M; Oncology Unit, Hospital CUF Tejo, Lisbon, Portugal, Oncology Unit, Unidade Local de Saúde Lisboa Ocidental, Lisbon, Portugal., van Ramshorst M; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Mueller V; Department of Gynecology, University Medical Center Hamburg 20246 Hamburg, Germany., Agostinetto E; Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Bruxelles, Belgium., Linn S; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands., Angelis M; IRCCS Istituto Neurologico Mediterraneo Neuromed, Division of Neurosurgery, Isernia, Italy., Schettini F; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Clinic Barcelona Comprehensive Cancer Center, Hospital Clinic of Barcelona, Barcelona, Spain; Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain., Giuliano M; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy. Electronic address: m.giuliano@unina.it.
Source: Cancer treatment reviews [Cancer Treat Rev] 2026 Jun; Vol. 147, pp. 103158. Date of Electronic Publication: 2026 May 17.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7502030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1967 (Electronic) Linking ISSN: 03057372 NLM ISO Abbreviation: Cancer Treat Rev Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Central nervous system and leptomeningeal metastases in patients with HER2-positive breast cancer: A comprehensive review and therapeutic algorithm proposal.
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  Data: <searchLink fieldCode="AU" term="%22Caltavituro+A%22">Caltavituro A</searchLink>; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Buonaiuto+R%22">Buonaiuto R</searchLink>; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Longobardi+A%22">Longobardi A</searchLink>; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Trasacco+P%22">Trasacco P</searchLink>; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Martinelli+C%22">Martinelli C</searchLink>; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Grazia+GD%22">Grazia GD</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pacelli+R%22">Pacelli R</searchLink>; Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Arpino+G%22">Arpino G</searchLink>; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Angelis+C%22">Angelis C</searchLink>; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Caputo+R%22">Caputo R</searchLink>; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Laurentiis+M%22">Laurentiis M</searchLink>; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Laakmann+E%22">Laakmann E</searchLink>; University Medical Center Hamburg-Eppendorf, Department of Gynecology, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22de+Matos+LV%22">de Matos LV</searchLink>; Breast Cancer Unit, Champalimaud Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Fontes-Sousa+M%22">Fontes-Sousa M</searchLink>; Oncology Unit, Hospital CUF Tejo, Lisbon, Portugal, Oncology Unit, Unidade Local de Saúde Lisboa Ocidental, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22van+Ramshorst+M%22">van Ramshorst M</searchLink>; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mueller+V%22">Mueller V</searchLink>; Department of Gynecology, University Medical Center Hamburg 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Agostinetto+E%22">Agostinetto E</searchLink>; Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Bruxelles, Belgium.<br /><searchLink fieldCode="AU" term="%22Linn+S%22">Linn S</searchLink>; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Angelis+M%22">Angelis M</searchLink>; IRCCS Istituto Neurologico Mediterraneo Neuromed, Division of Neurosurgery, Isernia, Italy.<br /><searchLink fieldCode="AU" term="%22Schettini+F%22">Schettini F</searchLink>; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Clinic Barcelona Comprehensive Cancer Center, Hospital Clinic of Barcelona, Barcelona, Spain; Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Giuliano+M%22">Giuliano M</searchLink>; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; Clinical and Translational Oncology, Scuola Superiore Meridionale, Naples, Italy. Electronic address: m.giuliano@unina.it.
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  Data: <searchLink fieldCode="JN" term="%227502030%22">Cancer treatment reviews</searchLink> [Cancer Treat Rev] 2026 Jun; Vol. 147, pp. 103158. <i>Date of Electronic Publication: </i>2026 May 17.
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