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Debio 0123, a WEE1 kinase inhibitor: Phase 1 results from dose escalation in patients with advanced solid tumors.

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Title: Debio 0123, a WEE1 kinase inhibitor: Phase 1 results from dose escalation in patients with advanced solid tumors.
Authors: Papadopoulos KP; START Center for Cancer Research, San Antonio, TX, USA. Electronic address: Kyri.Papadopoulos@startresearch.com., Sharma MR; START Center for Cancer Research - Midwest, Grand Rapids, MI, USA., Dummer R; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland., Colombo I; Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland., Ramelyte E; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland., Seamon L; START Center for Cancer Research - Midwest, Grand Rapids, MI, USA., Rasco DW; START Center for Cancer Research, San Antonio, TX, USA., Rodriguez-Freixinos V; Debiopharm International SA, Lausanne, Switzerland., Dozio V; Debiopharm International SA, Lausanne, Switzerland., Tat T; Debiopharm International SA, Lausanne, Switzerland., Luong N; Debiopharm International SA, Lausanne, Switzerland., Mathon C; Debiopharm International SA, Lausanne, Switzerland., Fuchs J; Debiopharm International SA, Lausanne, Switzerland., Massiere F; Debiopharm International SA, Lausanne, Switzerland., Hurynovich A; Debiopharm International SA, Lausanne, Switzerland., Omar M; Debiopharm International SA, Lausanne, Switzerland., Micallef S; Debiopharm International SA, Lausanne, Switzerland., Bellon A; Debiopharm International SA, Lausanne, Switzerland., Rodrigo Imedio E; Debiopharm International SA, Lausanne, Switzerland., Stathis A; Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 Jun 25; Vol. 242, pp. 116792. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Debio 0123, a WEE1 kinase inhibitor: Phase 1 results from dose escalation in patients with advanced solid tumors.
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  Data: <searchLink fieldCode="AU" term="%22Papadopoulos+KP%22">Papadopoulos KP</searchLink>; START Center for Cancer Research, San Antonio, TX, USA. Electronic address: Kyri.Papadopoulos@startresearch.com.<br /><searchLink fieldCode="AU" term="%22Sharma+MR%22">Sharma MR</searchLink>; START Center for Cancer Research - Midwest, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Dummer+R%22">Dummer R</searchLink>; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Colombo+I%22">Colombo I</searchLink>; Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ramelyte+E%22">Ramelyte E</searchLink>; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Seamon+L%22">Seamon L</searchLink>; START Center for Cancer Research - Midwest, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Rasco+DW%22">Rasco DW</searchLink>; START Center for Cancer Research, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Freixinos+V%22">Rodriguez-Freixinos V</searchLink>; Debiopharm International SA, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dozio+V%22">Dozio V</searchLink>; Debiopharm International SA, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tat+T%22">Tat T</searchLink>; Debiopharm International SA, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Luong+N%22">Luong N</searchLink>; Debiopharm International SA, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mathon+C%22">Mathon C</searchLink>; Debiopharm International SA, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fuchs+J%22">Fuchs J</searchLink>; Debiopharm International SA, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Massiere+F%22">Massiere F</searchLink>; Debiopharm International SA, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hurynovich+A%22">Hurynovich A</searchLink>; Debiopharm International SA, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Omar+M%22">Omar M</searchLink>; Debiopharm International SA, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Micallef+S%22">Micallef S</searchLink>; Debiopharm International SA, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bellon+A%22">Bellon A</searchLink>; Debiopharm International SA, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rodrigo+Imedio+E%22">Rodrigo Imedio E</searchLink>; Debiopharm International SA, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stathis+A%22">Stathis A</searchLink>; Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2026 Jun 25; Vol. 242, pp. 116792. <i>Date of Electronic Publication: </i>2026 May 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9005373 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0852 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209598049%22">09598049 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Cancer <i>Subsets: </i>MEDLINE
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