A Rahman Syndrome mutation in histone H1.4 disrupts chromatin compaction and phase separation.

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Title: A Rahman Syndrome mutation in histone H1.4 disrupts chromatin compaction and phase separation.
Authors: Boopathi R; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France., Garcia-Saez I; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France., Turunç S; Izmir Biomedicine and Genome Center, Dokuz Eylül University Health Campus, Izmir, Turkey.; Izmir International Biomedicine and Genome Institute, Dokuz Eylül University, Izmir, Turkey., Lone IN; Izmir Biomedicine and Genome Center, Dokuz Eylül University Health Campus, Izmir, Turkey., Kumar A; University of Rochester Medical Center, Rochester, NY, USA., Abu Alhaija AA; Izmir Biomedicine and Genome Center, Dokuz Eylül University Health Campus, Izmir, Turkey., Hayes JJ; University of Rochester Medical Center, Rochester, NY, USA., Bednar J; Univ. Grenoble Alpes, Inserm, CNRS, Institute for Advanced Biosciences (IAB), Grenoble, France., Diril MK; Izmir Biomedicine and Genome Center, Dokuz Eylül University Health Campus, Izmir, Turkey.; Izmir International Biomedicine and Genome Institute, Dokuz Eylül University, Izmir, Turkey., Iliev D; Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria., Gospodinov A; Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria., Le Roy A; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France., Skoufias D; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France., Angelov D; Izmir Biomedicine and Genome Center, Dokuz Eylül University Health Campus, Izmir, Turkey. dimitar_angelov@yahoo.com., Hamiche A; Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS, INSERM, Illkirch, France. hamiche@igbmc.fr., Kale S; Izmir Biomedicine and Genome Center, Dokuz Eylül University Health Campus, Izmir, Turkey. seyit.kale@ibg.edu.tr.; Faculty of Medicine, Izmir Katip Çelebi University, Izmir, Turkey. seyit.kale@ibg.edu.tr., Dimitrov S; Univ. Grenoble Alpes, Inserm, CNRS, Institute for Advanced Biosciences (IAB), Grenoble, France. stefan.dimitrov@univ-grenoble-alpes.fr.; Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria. stefan.dimitrov@univ-grenoble-alpes.fr., Petosa C; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France. carlo.petosa@ibs.fr.
Source: Nature communications [Nat Commun] 2026 May 22; Vol. 17 (1). Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-73046-8