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Doublecortin-like kinase 1 promotes fibroblast activation and fibrotic progression through Smad3 binding in idiopathic pulmonary fibrosis.

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Title: Doublecortin-like kinase 1 promotes fibroblast activation and fibrotic progression through Smad3 binding in idiopathic pulmonary fibrosis.
Authors: Lin LY; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan.; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Cheng WH; School of Respiratory Therapy, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan., Wu YC; School of Respiratory Therapy, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan., Wen HC; School of Respiratory Therapy, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan., Hsu HH; National Taiwan University Hospital & College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Surgical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan., Liu CH; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan., Chen JY; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan., Chang WS; School of Respiratory Therapy, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan., Wu YJ; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Wu JS; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Yuliani FS; Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Wang CY; Laboratory Animal Center, Taipei Medical University, Taipei, Taiwan., Lin CH; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan. chlin@tmu.edu.tw.; Chen Wei-Tien Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan. chlin@tmu.edu.tw., Chen BC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan. bcchen@tmu.edu.tw.; School of Respiratory Therapy, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan. bcchen@tmu.edu.tw.; Chen Wei-Tien Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan. bcchen@tmu.edu.tw.
Source: Journal of biomedical science [J Biomed Sci] 2026 May 22; Vol. 33 (1). Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127 (Electronic) Linking ISSN: 10217770 NLM ISO Abbreviation: J Biomed Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Doublecortin-like kinase 1 promotes fibroblast activation and fibrotic progression through Smad3 binding in idiopathic pulmonary fibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Lin+LY%22">Lin LY</searchLink>; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan.; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+WH%22">Cheng WH</searchLink>; School of Respiratory Therapy, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+YC%22">Wu YC</searchLink>; School of Respiratory Therapy, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wen+HC%22">Wen HC</searchLink>; School of Respiratory Therapy, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+HH%22">Hsu HH</searchLink>; National Taiwan University Hospital & College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Surgical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+CH%22">Liu CH</searchLink>; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+JY%22">Chen JY</searchLink>; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+WS%22">Chang WS</searchLink>; School of Respiratory Therapy, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+YJ%22">Wu YJ</searchLink>; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+JS%22">Wu JS</searchLink>; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yuliani+FS%22">Yuliani FS</searchLink>; Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.<br /><searchLink fieldCode="AU" term="%22Wang+CY%22">Wang CY</searchLink>; Laboratory Animal Center, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan. chlin@tmu.edu.tw.; Chen Wei-Tien Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan. chlin@tmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chen+BC%22">Chen BC</searchLink>; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan. bcchen@tmu.edu.tw.; School of Respiratory Therapy, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei, 110, Taiwan. bcchen@tmu.edu.tw.; Chen Wei-Tien Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan. bcchen@tmu.edu.tw.
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              Text: 2026 May 22
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