View in EDS HTML Full Text PDF Full Text

Safety and Efficacy of HexaBody-DR5/DR5 in Malignant Solid Tumors: Phase 1/2a Results and Translational Insights Into Observed Hepatotoxicity.

Saved in:
Bibliographic Details
Title: Safety and Efficacy of HexaBody-DR5/DR5 in Malignant Solid Tumors: Phase 1/2a Results and Translational Insights Into Observed Hepatotoxicity.
Authors: Overdijk MB; Genmab B.V., Utrecht, the Netherlands., Strumane K; Genmab B.V., Utrecht, the Netherlands., Plummer R; Newcastle University Translational and Clinical Research Institute, Medical School, Newcastle University, Newcastle upon Tyne, UK., LoRusso P; Yale Cancer Center, Yale University, New Haven, Connecticut, USA., Rodon Ahnert J; Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Banerji U; Institute of Cancer Research and the Royal Marsden, London, UK., Garralda E; Early Drug Development Unit, Vall d'Hebron Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Calvo E; START Madrid-CIOCC, Centro Integral Oncológico Clara Campal, Madrid, Spain., Si H; Genmab US, Inc., Plainsboro, New Jersey, USA., Hoevenaars N; Genmab B.V., Utrecht, the Netherlands., Mortensen JT; Genmab A/S, Copenhagen, Denmark., Bosgra S; Genmab B.V., Utrecht, the Netherlands., Malmberg A; Genmab A/S, Copenhagen, Denmark., Ellekilde-Pedersen M; Genmab A/S, Copenhagen, Denmark., Ramirez-Andersen T; Genmab A/S, Copenhagen, Denmark., Diamantopoulou Reiter P; Genmab A/S, Copenhagen, Denmark., Favaro E; Genmab A/S, Copenhagen, Denmark., Forssmann U; Genmab A/S, Copenhagen, Denmark., Breij ECW; Genmab B.V., Utrecht, the Netherlands., Jure-Kunkel M; Genmab US, Inc., Plainsboro, New Jersey, USA.
Source: Clinical and translational science [Clin Transl Sci] 2026 Jun; Vol. 19 (6), pp. e70546.
Publication Type: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42175632
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Safety and Efficacy of HexaBody-DR5/DR5 in Malignant Solid Tumors: Phase 1/2a Results and Translational Insights Into Observed Hepatotoxicity.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Overdijk+MB%22">Overdijk MB</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Strumane+K%22">Strumane K</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Plummer+R%22">Plummer R</searchLink>; Newcastle University Translational and Clinical Research Institute, Medical School, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22LoRusso+P%22">LoRusso P</searchLink>; Yale Cancer Center, Yale University, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Rodon+Ahnert+J%22">Rodon Ahnert J</searchLink>; Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Banerji+U%22">Banerji U</searchLink>; Institute of Cancer Research and the Royal Marsden, London, UK.<br /><searchLink fieldCode="AU" term="%22Garralda+E%22">Garralda E</searchLink>; Early Drug Development Unit, Vall d'Hebron Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Calvo+E%22">Calvo E</searchLink>; START Madrid-CIOCC, Centro Integral Oncológico Clara Campal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Si+H%22">Si H</searchLink>; Genmab US, Inc., Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Hoevenaars+N%22">Hoevenaars N</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mortensen+JT%22">Mortensen JT</searchLink>; Genmab A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bosgra+S%22">Bosgra S</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Malmberg+A%22">Malmberg A</searchLink>; Genmab A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ellekilde-Pedersen+M%22">Ellekilde-Pedersen M</searchLink>; Genmab A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ramirez-Andersen+T%22">Ramirez-Andersen T</searchLink>; Genmab A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Diamantopoulou+Reiter+P%22">Diamantopoulou Reiter P</searchLink>; Genmab A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Favaro+E%22">Favaro E</searchLink>; Genmab A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Forssmann+U%22">Forssmann U</searchLink>; Genmab A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Breij+ECW%22">Breij ECW</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Jure-Kunkel+M%22">Jure-Kunkel M</searchLink>; Genmab US, Inc., Plainsboro, New Jersey, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101474067%22">Clinical and translational science</searchLink> [Clin Transl Sci] 2026 Jun; Vol. 19 (6), pp. e70546.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22WileyBlackwell+Pub%22">WileyBlackwell Pub </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101474067 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1752-8062 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217528054%22">17528054 </searchLink><i>NLM ISO Abbreviation: </i>Clin Transl Sci <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42175632
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/cts.70546
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: e70546
    Titles:
      – TitleFull: Safety and Efficacy of HexaBody-DR5/DR5 in Malignant Solid Tumors: Phase 1/2a Results and Translational Insights Into Observed Hepatotoxicity.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Overdijk MB
      – PersonEntity:
          Name:
            NameFull: Strumane K
      – PersonEntity:
          Name:
            NameFull: Plummer R
      – PersonEntity:
          Name:
            NameFull: LoRusso P
      – PersonEntity:
          Name:
            NameFull: Rodon Ahnert J
      – PersonEntity:
          Name:
            NameFull: Banerji U
      – PersonEntity:
          Name:
            NameFull: Garralda E
      – PersonEntity:
          Name:
            NameFull: Calvo E
      – PersonEntity:
          Name:
            NameFull: Si H
      – PersonEntity:
          Name:
            NameFull: Hoevenaars N
      – PersonEntity:
          Name:
            NameFull: Mortensen JT
      – PersonEntity:
          Name:
            NameFull: Bosgra S
      – PersonEntity:
          Name:
            NameFull: Malmberg A
      – PersonEntity:
          Name:
            NameFull: Ellekilde-Pedersen M
      – PersonEntity:
          Name:
            NameFull: Ramirez-Andersen T
      – PersonEntity:
          Name:
            NameFull: Diamantopoulou Reiter P
      – PersonEntity:
          Name:
            NameFull: Favaro E
      – PersonEntity:
          Name:
            NameFull: Forssmann U
      – PersonEntity:
          Name:
            NameFull: Breij ECW
      – PersonEntity:
          Name:
            NameFull: Jure-Kunkel M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1752-8062
          Numbering:
            – Type: volume
              Value: 19
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Clinical and translational science
              Type: main
ResultId 1