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Safety and effectiveness of ETHIZIA versus TachoSil for hemostasis during open liver surgery: a randomized controlled multicenter trial.

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Title: Safety and effectiveness of ETHIZIA versus TachoSil for hemostasis during open liver surgery: a randomized controlled multicenter trial.
Authors: Guarrera JV; Department of Surgery, Sidney Kimmel Medical College at Thomas Jefferson University, 1025 Walnut Street, Suite 607, Philadelphia, PA, 19107, USA; Department of Surgery, Division of Liver Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School and University Hospital, 140 Bergen Street, Newark, NJ, 07101, USA. Electronic address: james.guarrera@jefferson.edu., Kaur N; Department of Surgery, Keck Hospital, University of Southern California, 1500 San Pablo Street, Los Angeles, CA, 90033, USA., Verhoef C; Department of Surgery, Erasmus MC Cancer Institute, University Hospital Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands., Zendejas I; Intermountain Medical Transplant Services, 5171 S. Cottonwood St, Murray, UT, 84107, USA., Botha J; Intermountain Medical Transplant Services, 5171 S. Cottonwood St, Murray, UT, 84107, USA., Fouraschen SMG; Department of Hepato-pancreato-biliary Surgery and Liver Transplantation, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands., Paterno F; Department of Surgery, Division of Liver Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School and University Hospital, 140 Bergen Street, Newark, NJ, 07101, USA., Pianka F; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany., Porte RJ; Department of Surgery, Erasmus MC Cancer Institute, University Hospital Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands., Samstein B; Department of Surgery, Weill Cornell Medicine, Payson 707, 525 East 68th Street, New York City, NY, 11065, USA., Sher L; Department of Surgery, Keck Hospital, University of Southern California, 1500 San Pablo Street, Los Angeles, CA, 90033, USA., Wellen JR; Section of Abdominal Transplant, Department of General Surgery, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO, 63110, USA., Bender JCME; GATT Technologies, A Johnson and Johnson Company, Transistorweg 5, 6534 AT, Nijmegen, the Netherlands., Fossan I; Johnson and Johnson, Transistorweg 5, 6534 AT, Nijmegen, the Netherlands., Head SJ; GATT Technologies, A Johnson and Johnson Company, Transistorweg 5, 6534 AT, Nijmegen, the Netherlands., de Wilt JHW; Department of Surgical Oncology, Radboud University Medical Center, Geert Grooteplein 10, 6500 HB, the Netherlands.
Corporate Authors: ETHIZIA Open Liver Study Collaborator Group
Source: HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2026 Aug; Vol. 28 (8), pp. 1064-1075. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Comparative Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 100900921 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2574 (Electronic) Linking ISSN: 1365182X NLM ISO Abbreviation: HPB (Oxford) Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Safety and effectiveness of ETHIZIA versus TachoSil for hemostasis during open liver surgery: a randomized controlled multicenter trial.
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  Data: <searchLink fieldCode="AU" term="%22Guarrera+JV%22">Guarrera JV</searchLink>; Department of Surgery, Sidney Kimmel Medical College at Thomas Jefferson University, 1025 Walnut Street, Suite 607, Philadelphia, PA, 19107, USA; Department of Surgery, Division of Liver Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School and University Hospital, 140 Bergen Street, Newark, NJ, 07101, USA. Electronic address: james.guarrera@jefferson.edu.<br /><searchLink fieldCode="AU" term="%22Kaur+N%22">Kaur N</searchLink>; Department of Surgery, Keck Hospital, University of Southern California, 1500 San Pablo Street, Los Angeles, CA, 90033, USA.<br /><searchLink fieldCode="AU" term="%22Verhoef+C%22">Verhoef C</searchLink>; Department of Surgery, Erasmus MC Cancer Institute, University Hospital Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zendejas+I%22">Zendejas I</searchLink>; Intermountain Medical Transplant Services, 5171 S. Cottonwood St, Murray, UT, 84107, USA.<br /><searchLink fieldCode="AU" term="%22Botha+J%22">Botha J</searchLink>; Intermountain Medical Transplant Services, 5171 S. Cottonwood St, Murray, UT, 84107, USA.<br /><searchLink fieldCode="AU" term="%22Fouraschen+SMG%22">Fouraschen SMG</searchLink>; Department of Hepato-pancreato-biliary Surgery and Liver Transplantation, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Paterno+F%22">Paterno F</searchLink>; Department of Surgery, Division of Liver Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School and University Hospital, 140 Bergen Street, Newark, NJ, 07101, USA.<br /><searchLink fieldCode="AU" term="%22Pianka+F%22">Pianka F</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Porte+RJ%22">Porte RJ</searchLink>; Department of Surgery, Erasmus MC Cancer Institute, University Hospital Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Samstein+B%22">Samstein B</searchLink>; Department of Surgery, Weill Cornell Medicine, Payson 707, 525 East 68th Street, New York City, NY, 11065, USA.<br /><searchLink fieldCode="AU" term="%22Sher+L%22">Sher L</searchLink>; Department of Surgery, Keck Hospital, University of Southern California, 1500 San Pablo Street, Los Angeles, CA, 90033, USA.<br /><searchLink fieldCode="AU" term="%22Wellen+JR%22">Wellen JR</searchLink>; Section of Abdominal Transplant, Department of General Surgery, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Bender+JCME%22">Bender JCME</searchLink>; GATT Technologies, A Johnson and Johnson Company, Transistorweg 5, 6534 AT, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Fossan+I%22">Fossan I</searchLink>; Johnson and Johnson, Transistorweg 5, 6534 AT, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Head+SJ%22">Head SJ</searchLink>; GATT Technologies, A Johnson and Johnson Company, Transistorweg 5, 6534 AT, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Wilt+JHW%22">de Wilt JHW</searchLink>; Department of Surgical Oncology, Radboud University Medical Center, Geert Grooteplein 10, 6500 HB, the Netherlands.
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  Data: <searchLink fieldCode="CA" term="%22ETHIZIA+Open+Liver+Study+Collaborator+Group%22">ETHIZIA Open Liver Study Collaborator Group</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22100900921%22">HPB : the official journal of the International Hepato Pancreato Biliary Association</searchLink> [HPB (Oxford)] 2026 Aug; Vol. 28 (8), pp. 1064-1075. <i>Date of Electronic Publication: </i>2026 May 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100900921 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-2574 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221365182X%22">1365182X </searchLink><i>NLM ISO Abbreviation: </i>HPB (Oxford) <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42177141
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        Value: 10.1016/j.hpb.2026.04.466
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        Text: English
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