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An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.

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Title: An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.
Authors: Mansourabadi AH; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Qu D; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Cianci F; Laboratory of Cellular and Molecular Physiology, Department of Biosciences, University of Milano, Milan, Italy., Snider J; Donnelly Center, University of Toronto, Toronto, ON, Canada., Randhawa K; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Raco L; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada., Kotlyar M; Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Center for Chronic Diseases, Krembil Research Institute, University Health Network, Toronto, ON, Canada., Al Ayach M; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Rey G; Laboratory of Cellular and Molecular Physiology, Department of Biosciences, University of Milano, Milan, Italy., Sanghvi S; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Abovsky M; Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Center for Chronic Diseases, Krembil Research Institute, University Health Network, Toronto, ON, Canada., Singh H; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Luchman HA; Department of Cell Biology and Anatomy, Arnie Charbonneau Cancer Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Burger D; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Kidney Research Center, Inflammation & Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Rak J; Department of Pediatrics, McGill University, Montreal, QC, Canada., Soleimani VD; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Jurisica I; Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Center for Chronic Diseases, Krembil Research Institute, University Health Network, Toronto, ON, Canada.; Departments of Medical Biophysics and Computer Science, and Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia., Stagljar I; Donnelly Center, University of Toronto, Toronto, ON, Canada. igor.stagljar@utoronto.ca.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. igor.stagljar@utoronto.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. igor.stagljar@utoronto.ca., Mazzanti M; Laboratory of Cellular and Molecular Physiology, Department of Biosciences, University of Milano, Milan, Italy. michele.mazzanti@unimi.it., Jahani-Asl A; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. arezu.jahani@uottawa.ca.; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada. arezu.jahani@uottawa.ca.; Ottawa Institute of Systems Biology, Ottawa, ON, Canada. arezu.jahani@uottawa.ca.; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada. arezu.jahani@uottawa.ca.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada. arezu.jahani@uottawa.ca.; Regenerative Medicine Program and Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. arezu.jahani@uottawa.ca.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada. arezu.jahani@uottawa.ca.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 May 23; Vol. 11 (1). Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Mansourabadi+AH%22">Mansourabadi AH</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Qu+D%22">Qu D</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Cianci+F%22">Cianci F</searchLink>; Laboratory of Cellular and Molecular Physiology, Department of Biosciences, University of Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Snider+J%22">Snider J</searchLink>; Donnelly Center, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Randhawa+K%22">Randhawa K</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Raco+L%22">Raco L</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Kotlyar+M%22">Kotlyar M</searchLink>; Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Center for Chronic Diseases, Krembil Research Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Al+Ayach+M%22">Al Ayach M</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Rey+G%22">Rey G</searchLink>; Laboratory of Cellular and Molecular Physiology, Department of Biosciences, University of Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sanghvi+S%22">Sanghvi S</searchLink>; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Abovsky+M%22">Abovsky M</searchLink>; Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Center for Chronic Diseases, Krembil Research Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Singh+H%22">Singh H</searchLink>; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Luchman+HA%22">Luchman HA</searchLink>; Department of Cell Biology and Anatomy, Arnie Charbonneau Cancer Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Burger+D%22">Burger D</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Kidney Research Center, Inflammation & Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Rak+J%22">Rak J</searchLink>; Department of Pediatrics, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Soleimani+VD%22">Soleimani VD</searchLink>; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Jurisica+I%22">Jurisica I</searchLink>; Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Center for Chronic Diseases, Krembil Research Institute, University Health Network, Toronto, ON, Canada.; Departments of Medical Biophysics and Computer Science, and Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.<br /><searchLink fieldCode="AU" term="%22Stagljar+I%22">Stagljar I</searchLink>; Donnelly Center, University of Toronto, Toronto, ON, Canada. igor.stagljar@utoronto.ca.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. igor.stagljar@utoronto.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. igor.stagljar@utoronto.ca.<br /><searchLink fieldCode="AU" term="%22Mazzanti+M%22">Mazzanti M</searchLink>; Laboratory of Cellular and Molecular Physiology, Department of Biosciences, University of Milano, Milan, Italy. michele.mazzanti@unimi.it.<br /><searchLink fieldCode="AU" term="%22Jahani-Asl+A%22">Jahani-Asl A</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. arezu.jahani@uottawa.ca.; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada. arezu.jahani@uottawa.ca.; Ottawa Institute of Systems Biology, Ottawa, ON, Canada. arezu.jahani@uottawa.ca.; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada. arezu.jahani@uottawa.ca.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada. arezu.jahani@uottawa.ca.; Regenerative Medicine Program and Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. arezu.jahani@uottawa.ca.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada. arezu.jahani@uottawa.ca.
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