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Aminoglycosides induce immune activation but is insufficient for systemic viral control: a double-blind randomized-controlled clinical trial.

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Title: Aminoglycosides induce immune activation but is insufficient for systemic viral control: a double-blind randomized-controlled clinical trial.
Authors: Sivanandam P; Duke-NUS Medical School, Singapore, Singapore., Syenina A; Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Chan YF; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore., Ng DH; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore., Gan ES; Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore., Yee JX; Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Tham CY; Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Tan HC; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Ong EZ; Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Ooi EE; Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.; Department of Clinical Translational Research, Singapore General Hospital, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Kalimuddin S; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore. shirin.kalimuddin@singhealth.com.sg.; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore. shirin.kalimuddin@singhealth.com.sg.
Source: Communications medicine [Commun Med (Lond)] 2026 May 23. Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918250414506676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2730-664X (Electronic) Linking ISSN: 2730664X NLM ISO Abbreviation: Commun Med (Lond)
Database: MEDLINE Ultimate
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  Data: Aminoglycosides induce immune activation but is insufficient for systemic viral control: a double-blind randomized-controlled clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Sivanandam+P%22">Sivanandam P</searchLink>; Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Syenina+A%22">Syenina A</searchLink>; Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+YF%22">Chan YF</searchLink>; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+DH%22">Ng DH</searchLink>; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Gan+ES%22">Gan ES</searchLink>; Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yee+JX%22">Yee JX</searchLink>; Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tham+CY%22">Tham CY</searchLink>; Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+HC%22">Tan HC</searchLink>; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+EZ%22">Ong EZ</searchLink>; Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ooi+EE%22">Ooi EE</searchLink>; Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.; Department of Clinical Translational Research, Singapore General Hospital, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kalimuddin+S%22">Kalimuddin S</searchLink>; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore. shirin.kalimuddin@singhealth.com.sg.; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore. shirin.kalimuddin@singhealth.com.sg.
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  Data: <searchLink fieldCode="JN" term="%229918250414506676%22">Communications medicine</searchLink> [Commun Med (Lond)] 2026 May 23. <i>Date of Electronic Publication: </i>2026 May 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Portfolio%22">Nature Portfolio </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918250414506676 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2730-664X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222730664X%22">2730664X </searchLink><i>NLM ISO Abbreviation: </i>Commun Med (Lond)
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        Value: 10.1038/s43856-026-01678-4
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              Text: 2026 May 23
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