View in EDS

Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.

Saved in:
Bibliographic Details
Title: Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.
Authors: Tyrmi JS; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere, Tampere University, Tampere, Finland. jaakko.tyrmi@tuni.fi.; Systems epidemiology, Research Unit of Population Health, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland. jaakko.tyrmi@tuni.fi., Karjalainen J; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland., Venkatesh SS; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Benoit-Pilven C; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland., Lemmelä SM; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland., Brunak S; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Aagaard B; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Bruun MT; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Pedersen OB; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Banasik K; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Mikkelsen C; Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Schwinn M; Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Sturluson A; deCODE genetics/Amgen, Reykjavik, Iceland., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Kettunen J; Systems epidemiology, Research Unit of Population Health, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland., Nielsen HS; Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark.; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Nyegaard M; Statens Serum Institut, Copenhagen, Denmark.; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Westergaard D; Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark., Rafnar T; deCODE genetics/Amgen, Reykjavik, Iceland., Sulem P; deCODE genetics/Amgen, Reykjavik, Iceland., Stefansson K; deCODE genetics/Amgen, Reykjavik, Iceland., Palta P; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Laisk T; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Tukiainen T; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland.; Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Lindgren CM; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Daly M; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Havulinna AS; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Computing, University of Turku, Turku, Finland., Laivuori HM; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere, Tampere University, Tampere, Finland.; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Obstetrics and Gynecology, Tampere University Hospital, The Wellbeing Services County of Pirkanmaa, Tampere, Finland.; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Corporate Authors: FinnGen, Estonian Biobank research team, DBDS Genomic Consortium
Source: Nature communications [Nat Commun] 2026 May 25. Date of Electronic Publication: 2026 May 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42178310
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Tyrmi+JS%22">Tyrmi JS</searchLink>; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere, Tampere University, Tampere, Finland. jaakko.tyrmi@tuni.fi.; Systems epidemiology, Research Unit of Population Health, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland. jaakko.tyrmi@tuni.fi.<br /><searchLink fieldCode="AU" term="%22Karjalainen+J%22">Karjalainen J</searchLink>; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Venkatesh+SS%22">Venkatesh SS</searchLink>; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Benoit-Pilven+C%22">Benoit-Pilven C</searchLink>; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Lemmelä+SM%22">Lemmelä SM</searchLink>; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Brunak+S%22">Brunak S</searchLink>; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Aagaard+B%22">Aagaard B</searchLink>; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Bruun+MT%22">Bruun MT</searchLink>; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Erikstrup+C%22">Erikstrup C</searchLink>; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Ullum+H%22">Ullum H</searchLink>; Statens Serum Institut, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Pedersen+OB%22">Pedersen OB</searchLink>; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Banasik+K%22">Banasik K</searchLink>; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sørensen+E%22">Sørensen E</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Mikkelsen+C%22">Mikkelsen C</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Schwinn+M%22">Schwinn M</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sturluson+A%22">Sturluson A</searchLink>; deCODE genetics/Amgen, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Ostrowski+SR%22">Ostrowski SR</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Kettunen+J%22">Kettunen J</searchLink>; Systems epidemiology, Research Unit of Population Health, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Nielsen+HS%22">Nielsen HS</searchLink>; Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark.; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Nyegaard+M%22">Nyegaard M</searchLink>; Statens Serum Institut, Copenhagen, Denmark.; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Westergaard+D%22">Westergaard D</searchLink>; Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rafnar+T%22">Rafnar T</searchLink>; deCODE genetics/Amgen, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Sulem+P%22">Sulem P</searchLink>; deCODE genetics/Amgen, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Stefansson+K%22">Stefansson K</searchLink>; deCODE genetics/Amgen, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Palta+P%22">Palta P</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Laisk+T%22">Laisk T</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Tukiainen+T%22">Tukiainen T</searchLink>; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland.; Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Lindgren+CM%22">Lindgren CM</searchLink>; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Daly+M%22">Daly M</searchLink>; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Havulinna+AS%22">Havulinna AS</searchLink>; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Computing, University of Turku, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Laivuori+HM%22">Laivuori HM</searchLink>; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere, Tampere University, Tampere, Finland.; Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Obstetrics and Gynecology, Tampere University Hospital, The Wellbeing Services County of Pirkanmaa, Tampere, Finland.; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
– Name: AuthorCorporate
  Label: Corporate Authors
  Group: Au
  Data: <searchLink fieldCode="CA" term="%22FinnGen%22">FinnGen</searchLink><br /><searchLink fieldCode="CA" term="%22Estonian+Biobank+research+team%22">Estonian Biobank research team</searchLink><br /><searchLink fieldCode="CA" term="%22DBDS+Genomic+Consortium%22">DBDS Genomic Consortium</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 May 25. <i>Date of Electronic Publication: </i>2026 May 25.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42178310
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-026-73122-z
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Tyrmi JS
      – PersonEntity:
          Name:
            NameFull: Karjalainen J
      – PersonEntity:
          Name:
            NameFull: Venkatesh SS
      – PersonEntity:
          Name:
            NameFull: Benoit-Pilven C
      – PersonEntity:
          Name:
            NameFull: Lemmelä SM
      – PersonEntity:
          Name:
            NameFull: Brunak S
      – PersonEntity:
          Name:
            NameFull: Aagaard B
      – PersonEntity:
          Name:
            NameFull: Bruun MT
      – PersonEntity:
          Name:
            NameFull: Erikstrup C
      – PersonEntity:
          Name:
            NameFull: Ullum H
      – PersonEntity:
          Name:
            NameFull: Pedersen OB
      – PersonEntity:
          Name:
            NameFull: Banasik K
      – PersonEntity:
          Name:
            NameFull: Sørensen E
      – PersonEntity:
          Name:
            NameFull: Mikkelsen C
      – PersonEntity:
          Name:
            NameFull: Schwinn M
      – PersonEntity:
          Name:
            NameFull: Sturluson A
      – PersonEntity:
          Name:
            NameFull: Ostrowski SR
      – PersonEntity:
          Name:
            NameFull: Kettunen J
      – PersonEntity:
          Name:
            NameFull: Nielsen HS
      – PersonEntity:
          Name:
            NameFull: Nyegaard M
      – PersonEntity:
          Name:
            NameFull: Westergaard D
      – PersonEntity:
          Name:
            NameFull: Rafnar T
      – PersonEntity:
          Name:
            NameFull: Sulem P
      – PersonEntity:
          Name:
            NameFull: Stefansson K
      – PersonEntity:
          Name:
            NameFull: Palta P
      – PersonEntity:
          Name:
            NameFull: Laisk T
      – PersonEntity:
          Name:
            NameFull: Tukiainen T
      – PersonEntity:
          Name:
            NameFull: Lindgren CM
      – PersonEntity:
          Name:
            NameFull: Daly M
      – PersonEntity:
          Name:
            NameFull: Havulinna AS
      – PersonEntity:
          Name:
            NameFull: Laivuori HM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 25
              M: 05
              Text: 2026 May 25
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1