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Artesunate overcomes oxaliplatin resistance in colorectal cancer by inducing ferroptosis through inhibition of the CDK5/Nrf2/GPX4 pathway.

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Title: Artesunate overcomes oxaliplatin resistance in colorectal cancer by inducing ferroptosis through inhibition of the CDK5/Nrf2/GPX4 pathway.
Authors: Lv F; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China., Li XH; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China., Li SQ; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China., Deng HW; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China., Wei HT; Department of Gastrointestinal Surgery, Third Affiliated Hospital of Guangxi Medical University, Nanning, 530031, China., Li KZ; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China., Xie MZ; Department of Medical Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China., Xie LY; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China., Ning SF; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China., Hu BL; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China. hubangli@gxmu.edu.cn.
Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2026 May 24; Vol. 31 (6). Date of Electronic Publication: 2026 May 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Artesunate overcomes oxaliplatin resistance in colorectal cancer by inducing ferroptosis through inhibition of the CDK5/Nrf2/GPX4 pathway.
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  Data: <searchLink fieldCode="AU" term="%22Lv+F%22">Lv F</searchLink>; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Li+XH%22">Li XH</searchLink>; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Li+SQ%22">Li SQ</searchLink>; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Deng+HW%22">Deng HW</searchLink>; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Wei+HT%22">Wei HT</searchLink>; Department of Gastrointestinal Surgery, Third Affiliated Hospital of Guangxi Medical University, Nanning, 530031, China.<br /><searchLink fieldCode="AU" term="%22Li+KZ%22">Li KZ</searchLink>; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Xie+MZ%22">Xie MZ</searchLink>; Department of Medical Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Xie+LY%22">Xie LY</searchLink>; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Ning+SF%22">Ning SF</searchLink>; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Hu+BL%22">Hu BL</searchLink>; Department of Experimental Research, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning, 530021, Guangxi, China. hubangli@gxmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229712129%22">Apoptosis : an international journal on programmed cell death</searchLink> [Apoptosis] 2026 May 24; Vol. 31 (6). <i>Date of Electronic Publication: </i>2026 May 24.
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9712129 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-675X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213608185%22">13608185 </searchLink><i>NLM ISO Abbreviation: </i>Apoptosis <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10495-026-02362-7
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      – Code: eng
        Text: English
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      – TitleFull: Artesunate overcomes oxaliplatin resistance in colorectal cancer by inducing ferroptosis through inhibition of the CDK5/Nrf2/GPX4 pathway.
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            – D: 24
              M: 05
              Text: 2026 May 24
              Type: published
              Y: 2026
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