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Distinct 2-phenylimidazo[1,2-a]pyridine derivatives that inhibit breast cancer cell proliferation identified as AHR ligands.

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Title: Distinct 2-phenylimidazo[1,2-a]pyridine derivatives that inhibit breast cancer cell proliferation identified as AHR ligands.
Authors: Koellisch K; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Blattner C; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Motta S; Department of Earth and Environmental Sciences, University of Milano-Bicocca, Piazza della Scienza 1, 20126 Milan, Italy., Wesslowski J; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Rothley M; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Büchel S; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Sirounian S; CBS (Centre de Biologie Structurale), University Montpellier, CNRS, Inserm, Montpellier, France., Segatto I; Unit of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, National Cancer Institute, Aviano, Italy., Weber HT; European Center for Angioscience, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany., Müller J; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Grimaldi M; IRCM (Institut de Recherche en Cancérologie de Montpellier), Inserm U1194, University Montpellier, ICM, Montpellier, France., Stober J; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Wammetsberger Z; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Pan M; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Houtman R; Precision Medicine Lab, Oss, the Netherlands., Grathwol CW; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Lin LW; Cancer Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA., Buluwela L; Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK., Kolluri SK; Cancer Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.; Linus Pauling Institute, Oregon State University, Corvallis, OR, USA., Mytzka D; Institute of Pharmacy and Molecular Biotechnology IPMB, Heidelberg University, 69120 Heidelberg, Germany., Ali S; Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK., Jung N; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Balaguer P; IRCM (Institut de Recherche en Cancérologie de Montpellier), Inserm U1194, University Montpellier, ICM, Montpellier, France., Thaler S; European Center for Angioscience, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany., Belletti B; Unit of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, National Cancer Institute, Aviano, Italy., Bonati L; Department of Earth and Environmental Sciences, University of Milano-Bicocca, Piazza della Scienza 1, 20126 Milan, Italy., Bourguet W; CBS (Centre de Biologie Structurale), University Montpellier, CNRS, Inserm, Montpellier, France., Bräse S; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.; Institute of Organic Chemistry, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Davidson G; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany., Cato ACB; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.
Source: IScience [iScience] 2026 Apr 29; Vol. 29 (6), pp. 115936. Date of Electronic Publication: 2026 Apr 29 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: Distinct 2-phenylimidazo[1,2-a]pyridine derivatives that inhibit breast cancer cell proliferation identified as AHR ligands.
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  Data: <searchLink fieldCode="AU" term="%22Koellisch+K%22">Koellisch K</searchLink>; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Blattner+C%22">Blattner C</searchLink>; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Motta+S%22">Motta S</searchLink>; Department of Earth and Environmental Sciences, University of Milano-Bicocca, Piazza della Scienza 1, 20126 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Wesslowski+J%22">Wesslowski J</searchLink>; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Rothley+M%22">Rothley M</searchLink>; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Büchel+S%22">Büchel S</searchLink>; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Sirounian+S%22">Sirounian S</searchLink>; CBS (Centre de Biologie Structurale), University Montpellier, CNRS, Inserm, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Segatto+I%22">Segatto I</searchLink>; Unit of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, National Cancer Institute, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Weber+HT%22">Weber HT</searchLink>; European Center for Angioscience, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+J%22">Müller J</searchLink>; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Grimaldi+M%22">Grimaldi M</searchLink>; 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Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Lin+LW%22">Lin LW</searchLink>; Cancer Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.<br /><searchLink fieldCode="AU" term="%22Buluwela+L%22">Buluwela L</searchLink>; Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Kolluri+SK%22">Kolluri SK</searchLink>; Cancer Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.; Linus Pauling Institute, Oregon State University, Corvallis, OR, USA.<br /><searchLink fieldCode="AU" term="%22Mytzka+D%22">Mytzka D</searchLink>; Institute of Pharmacy and Molecular Biotechnology IPMB, Heidelberg University, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ali+S%22">Ali S</searchLink>; 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CBS (Centre de Biologie Structurale), University Montpellier, CNRS, Inserm, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Bräse+S%22">Bräse S</searchLink>; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.; Institute of Organic Chemistry, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Davidson+G%22">Davidson G</searchLink>; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Cato+ACB%22">Cato ACB</searchLink>; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101724038%22">IScience</searchLink> [iScience] 2026 Apr 29; Vol. 29 (6), pp. 115936. <i>Date of Electronic Publication: </i>2026 Apr 29 (<i>Print Publication: </i>2026).
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