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Targeting PIP5K ameliorates hepatic cancer by inhibiting PI3K/AKT and the autophagy mechanism and enhancing ROS-mediated apoptosis.

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Title: Targeting PIP5K ameliorates hepatic cancer by inhibiting PI3K/AKT and the autophagy mechanism and enhancing ROS-mediated apoptosis.
Authors: Shantanu PA; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India., Rajdev B; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India., Syamprasad NP; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India., Gangasani JK; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India., Mandal A; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India., Panda SR; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India., Sistla R; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, Telangana, India., Andugulapati SB; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, Telangana, India., Sarin SK; Liver Physiology and Vascular Biology Lab, Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences (ILBS), New Delhi, India., Tripathi DM; Liver Physiology and Vascular Biology Lab, Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences (ILBS), New Delhi, India., Naidu VGM; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 May 08; Vol. 17, pp. 1791462. Date of Electronic Publication: 2026 May 08 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting PIP5K ameliorates hepatic cancer by inhibiting PI3K/AKT and the autophagy mechanism and enhancing ROS-mediated apoptosis.
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  Data: <searchLink fieldCode="AU" term="%22Shantanu+PA%22">Shantanu PA</searchLink>; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India.<br /><searchLink fieldCode="AU" term="%22Rajdev+B%22">Rajdev B</searchLink>; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India.<br /><searchLink fieldCode="AU" term="%22Syamprasad+NP%22">Syamprasad NP</searchLink>; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India.<br /><searchLink fieldCode="AU" term="%22Gangasani+JK%22">Gangasani JK</searchLink>; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India.<br /><searchLink fieldCode="AU" term="%22Mandal+A%22">Mandal A</searchLink>; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India.<br /><searchLink fieldCode="AU" term="%22Panda+SR%22">Panda SR</searchLink>; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India.<br /><searchLink fieldCode="AU" term="%22Sistla+R%22">Sistla R</searchLink>; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, Telangana, India.<br /><searchLink fieldCode="AU" term="%22Andugulapati+SB%22">Andugulapati SB</searchLink>; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, Telangana, India.<br /><searchLink fieldCode="AU" term="%22Sarin+SK%22">Sarin SK</searchLink>; Liver Physiology and Vascular Biology Lab, Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences (ILBS), New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Tripathi+DM%22">Tripathi DM</searchLink>; Liver Physiology and Vascular Biology Lab, Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences (ILBS), New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Naidu+VGM%22">Naidu VGM</searchLink>; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research Guwahati, Guwahati, Assam, India.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2026 May 08; Vol. 17, pp. 1791462. <i>Date of Electronic Publication: </i>2026 May 08 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media]%22">Frontiers Media] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101548923 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-9812 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216639812%22">16639812 </searchLink><i>NLM ISO Abbreviation: </i>Front Pharmacol <i>Subsets: </i>PubMed not MEDLINE
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