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AEGIS reveals epitope- and clone-resolved convergence of CNS B and T cell autoreactivity in ROHHAD.

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Title: AEGIS reveals epitope- and clone-resolved convergence of CNS B and T cell autoreactivity in ROHHAD.
Authors: Bodansky A; Department of Pediatric Critical Medicine, University of California San Francisco; San Francisco, CA.; Child Health Advanced Molecular Phenotyping (CHAMP) Program, University of California San Francisco; San Francisco, CA., Ahyong V; Department of Biochemistry and Biophysics, University of California San Francisco; San Francisco, CA., Dayao M; Chan Zuckerberg Biohub San Francisco; San Francisco, CA., Asaki J; Biomedical Sciences Program, University of California San Francisco, San Francisco, CA., Vanasupa S; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Dandekar R; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Chen S; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Sabatino J; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Klauer S; Department of Pediatric Critical Medicine, University of California San Francisco; San Francisco, CA.; Child Health Advanced Molecular Phenotyping (CHAMP) Program, University of California San Francisco; San Francisco, CA., Knudsen G; Alaunus Biosciences; San Francisco, CA., Valenzuela CL; Department of Pediatric Critical Medicine, University of California San Francisco; San Francisco, CA.; Child Health Advanced Molecular Phenotyping (CHAMP) Program, University of California San Francisco; San Francisco, CA., McCutcheon K; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Zorn K; Child Health Advanced Molecular Phenotyping (CHAMP) Program, University of California San Francisco; San Francisco, CA.; Department of Biochemistry and Biophysics, University of California San Francisco; San Francisco, CA., Sidhu S; Child Health Advanced Molecular Phenotyping (CHAMP) Program, University of California San Francisco; San Francisco, CA.; Department of Biochemistry and Biophysics, University of California San Francisco; San Francisco, CA., Yu D; Diabetes Center, School of Medicine, University of California San Francisco, San Francisco, CA., Garcia S; Diabetes Center, School of Medicine, University of California San Francisco, San Francisco, CA., Quandt Z; Diabetes Center, School of Medicine, University of California San Francisco, San Francisco, CA.; Department of Medicine, Division of Endocrinology, University of California San Francisco; San Francisco, CA., Wang CY; Chan Zuckerberg Biohub San Francisco; San Francisco, CA., Rojas BC; Chan Zuckerberg Biohub San Francisco; San Francisco, CA., Tilton I; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Citron YR; Department of Biochemistry and Biophysics, University of California San Francisco; San Francisco, CA., Sharathchandra A; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Gerungan C; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Tomko S; Washington University in Saint Louis, Department of Neurology, Campus Box 8111, 660 S. Euclid Ave, Saint Louis, MO 63110, United States of America., Robbins NM; Harvard Medical School, Department of Neurology, Boston, MA 02115.; Mass General Brigham Department of Neurology, Boston, MA, 02114., McKeon A; Department of Neurology, Mayo Clinic, Rochester, MN.; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Cooper T; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Harms M; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Gomez R; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Fancy SPJ; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Green AJ; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Caliskan I; Department of Pathology, University of California San Francisco, San Francisco, California., Cadwell CR; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA.; Department of Pathology, University of California San Francisco, San Francisco, California.; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA. TBD., Ostrem BE; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Karalius M; Department of Neurology and Pediatrics, University of California San Francisco, San Francisco, CA,USA., Braun L; Department of Pediatric Critical Medicine, University of California San Francisco; San Francisco, CA., Gupta S; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Francisco C; Department of Neurology and Pediatrics, University of California San Francisco, San Francisco, CA,USA., Peng G; Department of Neurology and Pediatrics, University of California San Francisco, San Francisco, CA,USA., Reddy AT; Departments of Neurology, Neurosurgery and Pediatrics, University of California San Francisco, San Francisco, CA, USA., Nash K; Department of Neurology and Pediatrics, University of California San Francisco, San Francisco, CA,USA., Pleasure SJ; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Mandel-Brehm C; Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA., Arnold TD; Department of Pediatric Critical Medicine, University of California San Francisco; San Francisco, CA.; Child Health Advanced Molecular Phenotyping (CHAMP) Program, University of California San Francisco; San Francisco, CA., Anderson MS; Chan Zuckerberg Biohub San Francisco; San Francisco, CA.; Diabetes Center, School of Medicine, University of California San Francisco, San Francisco, CA.; Department of Medicine, Division of Endocrinology, University of California San Francisco; San Francisco, CA., Gerdts J; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., Wilson MR; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco; San Francisco, CA., DeRisi JL; Department of Biochemistry and Biophysics, University of California San Francisco; San Francisco, CA.; Chan Zuckerberg Biohub San Francisco; San Francisco, CA.
Corporate Authors: BRUNO Consortium
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 11. Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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