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LVV SMRTcap reveals extensive proviral variation in lentiviral vector-transduced CAR T cells.

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Title: LVV SMRTcap reveals extensive proviral variation in lentiviral vector-transduced CAR T cells.
Authors: Kaiser CW; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, USA., Mehs GS; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, USA., Elliott EM; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, USA., Mroczkowska JE; Department of Pediatrics Division of Hematology, Oncology and Stem Cell Transplantation, University of Louisville School of Medicine, Louisville, KY, USA., Jain A; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ferguson M; Department of Pediatrics Division of Hematology, Oncology and Stem Cell Transplantation, University of Louisville School of Medicine, Louisville, KY, USA., Garfall AL; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bushman FD; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Fraietta JA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rouchka EC; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, USA.; Kentucky Biomedical Research Infrastructure Network Data Science Core, University of Louisville, Louisville, KY, USA., Smith ML; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 15. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: LVV SMRTcap reveals extensive proviral variation in lentiviral vector-transduced CAR T cells.
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  Data: <searchLink fieldCode="AU" term="%22Kaiser+CW%22">Kaiser CW</searchLink>; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Mehs+GS%22">Mehs GS</searchLink>; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Elliott+EM%22">Elliott EM</searchLink>; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Mroczkowska+JE%22">Mroczkowska JE</searchLink>; Department of Pediatrics Division of Hematology, Oncology and Stem Cell Transplantation, University of Louisville School of Medicine, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Jain+A%22">Jain A</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ferguson+M%22">Ferguson M</searchLink>; Department of Pediatrics Division of Hematology, Oncology and Stem Cell Transplantation, University of Louisville School of Medicine, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Garfall+AL%22">Garfall AL</searchLink>; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bushman+FD%22">Bushman FD</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Fraietta+JA%22">Fraietta JA</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rouchka+EC%22">Rouchka EC</searchLink>; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, USA.; Kentucky Biomedical Research Infrastructure Network Data Science Core, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Smith+ML%22">Smith ML</searchLink>; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, USA.
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              Text: 2026 May 15
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