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Pathogen-specific host responses define distinct pneumonia endotypes in the human lung.

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Title: Pathogen-specific host responses define distinct pneumonia endotypes in the human lung.
Authors: Markov NS; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Możejko M; Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland., Guggilla V; Division of Biostatistics and Informatics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Łazęcka M; Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland., Donnelly HK; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Donayre A; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Fenske S; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Peltekian A; Department of Computer Science, Northwestern University McCormick School of Engineering and Applied Science, Chicago, IL, USA., Puczko-Szymański B; Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland., Szymczak P; Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland.; Institute of AI for Health, Helmholtz Zentrum Munchen, Munich, Germany., Izdebski A; Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland.; Institute of AI for Health, Helmholtz Zentrum Munchen, Munich, Germany., Luo L; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Senkow KJ; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Cusick L; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Yu Z; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Swaminathan S; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Lu Z; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Abdala-Valencia H; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Phan D; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Clepp RK; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Rasmussen LV; Division of Biostatistics and Informatics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Pawlowski A; Northwestern Medicine Enterprise Data Warehouse, Chicago, IL, USA., Pickens CO; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Nadig NR; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Walunas T; Division of General Internal Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Tighe RM; Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Duke University, Durham, NC, USA., Morales-Nebreda L; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Gao CA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Wunderink RG; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Budinger GS; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Singer BD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Misharin AV; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Szczurek E; Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland.; Institute of AI for Health, Helmholtz Zentrum Munchen, Munich, Germany.
Corporate Authors: Neu-Lung Investigators, NU SCRIPT Study Investigators
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 14. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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