Characterization of the Second-Generation Covalent Fragment Library (CovLib Gen2): Thiol Reactivity Profiling and p53-Y220C Rescue.
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| Title: | Characterization of the Second-Generation Covalent Fragment Library (CovLib Gen2): Thiol Reactivity Profiling and p53-Y220C Rescue. |
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| Authors: | Schwer M; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany., Aldea SR; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany., Engelhardt MU; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany., Stahlecker J; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany., Rheinganz J; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany., Langkamp A; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany., Boeckler FM; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany.; Interfaculty Institute for Biomedical Informatics (IBMI), Eberhard Karls Universität Tübingen, Tübingen, 72076, Germany. |
| Source: | Drug design, development and therapy [Drug Des Devel Ther] 2026 May 18; Vol. 20, pp. 598622. Date of Electronic Publication: 2026 May 18 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1177-8881 |
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| DOI: | 10.2147/DDDT.S598622 |
