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Characterization of the Second-Generation Covalent Fragment Library (CovLib Gen2): Thiol Reactivity Profiling and p53-Y220C Rescue.

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Title: Characterization of the Second-Generation Covalent Fragment Library (CovLib Gen2): Thiol Reactivity Profiling and p53-Y220C Rescue.
Authors: Schwer M; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany., Aldea SR; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany., Engelhardt MU; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany., Stahlecker J; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany., Rheinganz J; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany., Langkamp A; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany., Boeckler FM; Department of Pharmacy and Biochemistry, Laboratory for Molecular Design & Pharmaceutical Biophysics, Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany.; Interfaculty Institute for Biomedical Informatics (IBMI), Eberhard Karls Universität Tübingen, Tübingen, 72076, Germany.
Source: Drug design, development and therapy [Drug Des Devel Ther] 2026 May 18; Vol. 20, pp. 598622. Date of Electronic Publication: 2026 May 18 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Characterization of the Second-Generation Covalent Fragment Library (CovLib Gen2): Thiol Reactivity Profiling and p53-Y220C Rescue.
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