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Metabolomics-based predictive biomarker discovery for thiopurine response in Crohn disease: Plasma histidine as a promising biomarker.

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Title: Metabolomics-based predictive biomarker discovery for thiopurine response in Crohn disease: Plasma histidine as a promising biomarker.
Authors: Chan SY; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China., Chao K; Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Yang T; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China; Department of Pharmacy, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China., Cao AL; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China., Guan YP; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China., Li P; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China; School of Medicine, Jianghan University, Wuhan, China., Guan SX; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China., Yu AM; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, California., Zuo Z; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China., Wang XD; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China. Electronic address: wangxd@mail.sysu.edu.cn., Gao X; Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address: gxiang@mail.sysu.edu.cn., Huang M; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China. Electronic address: huangmin@mail.sysu.edu.cn.
Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2026 Jun; Vol. 54 (6), pp. 100297. Date of Electronic Publication: 2026 Apr 13.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Metabolomics-based predictive biomarker discovery for thiopurine response in Crohn disease: Plasma histidine as a promising biomarker.
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  Data: <searchLink fieldCode="AU" term="%22Chan+SY%22">Chan SY</searchLink>; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chao+K%22">Chao K</searchLink>; Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China; Department of Pharmacy, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Cao+AL%22">Cao AL</searchLink>; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Guan+YP%22">Guan YP</searchLink>; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China; School of Medicine, Jianghan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Guan+SX%22">Guan SX</searchLink>; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yu+AM%22">Yu AM</searchLink>; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, California.<br /><searchLink fieldCode="AU" term="%22Zuo+Z%22">Zuo Z</searchLink>; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Wang+XD%22">Wang XD</searchLink>; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China. Electronic address: wangxd@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Gao+X%22">Gao X</searchLink>; Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address: gxiang@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Huang+M%22">Huang M</searchLink>; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China. Electronic address: huangmin@mail.sysu.edu.cn.
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              Text: 2026 Jun
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