Targeting dysregulated glycolysis in type 2 diabetic osteoporosis: Identification of a diagnostic gene signature and therapeutic validation of calcifediol.
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| Title: | Targeting dysregulated glycolysis in type 2 diabetic osteoporosis: Identification of a diagnostic gene signature and therapeutic validation of calcifediol. |
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| Authors: | Li M; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China., Li W; Guangdong Pharmaceutical University, College of traditional Chinese medicine, Yunfu, Guangdong, 510006, PR China., Mai G; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China., Pan Z; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, PR China; Third School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China., Xiao J; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China., Ma J; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China., Wang F; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China., Chen B; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; Fifth School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China., Meng C; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China., Zhang J; Guangdong Pharmaceutical University, College of traditional Chinese medicine, Yunfu, Guangdong, 510006, PR China., Wang H; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; Department of Orthopaedic Surgery, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 16 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China. Electronic address: wanghaibin0058@gzucm.edu.cn., He J; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; Department of Orthopaedic Surgery, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 16 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China. Electronic address: hejiandong10077@gzucm.edu.cn. |
| Source: | Life sciences [Life Sci] 2026 Sep 01; Vol. 400, pp. 124473. Date of Electronic Publication: 2026 May 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42184924 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Targeting dysregulated glycolysis in type 2 diabetic osteoporosis: Identification of a diagnostic gene signature and therapeutic validation of calcifediol. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Guangdong Pharmaceutical University, College of traditional Chinese medicine, Yunfu, Guangdong, 510006, PR China.<br /><searchLink fieldCode="AU" term="%22Mai+G%22">Mai G</searchLink>; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China.<br /><searchLink fieldCode="AU" term="%22Pan+Z%22">Pan Z</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, PR China; Third School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China.<br /><searchLink fieldCode="AU" term="%22Xiao+J%22">Xiao J</searchLink>; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China.<br /><searchLink fieldCode="AU" term="%22Chen+B%22">Chen B</searchLink>; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; Fifth School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China.<br /><searchLink fieldCode="AU" term="%22Meng+C%22">Meng C</searchLink>; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Guangdong Pharmaceutical University, College of traditional Chinese medicine, Yunfu, Guangdong, 510006, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; Department of Orthopaedic Surgery, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 16 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China. Electronic address: wanghaibin0058@gzucm.edu.cn.<br /><searchLink fieldCode="AU" term="%22He+J%22">He J</searchLink>; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China; Department of Orthopaedic Surgery, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 16 Jichang Road, Baiyun District, Guangzhou, Guangdong, 510405, PR China. Electronic address: hejiandong10077@gzucm.edu.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220375521%22">Life sciences</searchLink> [Life Sci] 2026 Sep 01; Vol. 400, pp. 124473. <i>Date of Electronic Publication: </i>2026 May 25. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0375521 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0631 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200243205%22">00243205 </searchLink><i>NLM ISO Abbreviation: </i>Life Sci <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42184924 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.lfs.2026.124473 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 124473 Titles: – TitleFull: Targeting dysregulated glycolysis in type 2 diabetic osteoporosis: Identification of a diagnostic gene signature and therapeutic validation of calcifediol. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li M – PersonEntity: Name: NameFull: Li W – PersonEntity: Name: NameFull: Mai G – PersonEntity: Name: NameFull: Pan Z – PersonEntity: Name: NameFull: Xiao J – PersonEntity: Name: NameFull: Ma J – PersonEntity: Name: NameFull: Wang F – PersonEntity: Name: NameFull: Chen B – PersonEntity: Name: NameFull: Meng C – PersonEntity: Name: NameFull: Zhang J – PersonEntity: Name: NameFull: Wang H – PersonEntity: Name: NameFull: He J IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: 2026 Sep 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1879-0631 Numbering: – Type: volume Value: 400 Titles: – TitleFull: Life sciences Type: main |
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