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Dehydration promotes intracellular lipid synthesis and accumulation.

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Title: Dehydration promotes intracellular lipid synthesis and accumulation.
Authors: Carty JS; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Selvasingh J; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Zuchowski Y; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Nam HJ; Molecular Medicine Program, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA., Pénalva C; Molecular Medicine Program, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA., Nanayakkara G; Molecular Medicine Program, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA., Jennings EQ; Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Voss K; Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.; Department of Pharmacology, University of Virginia, Charlottesville, VA, USA., Adame ET; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Tossberg JT; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Yap WS; Cell Biology Program, Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Melzer M; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Viquez O; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., McCall AS; Division of Allergy, Pulmonary, and Critical Care, Department of Medicine, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Piotrowski ER; Department of Integrative Biology, University of California, Berkeley, CA, USA., Bessho R; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Cao S; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Leaptrot KL; Department of Chemistry and Center for Innovative Technology; Vanderbilt University, Nashville, TN, USA., Schrimpe-Rutledge AC; Department of Chemistry and Center for Innovative Technology; Vanderbilt University, Nashville, TN, USA., Codreanu SG; Department of Chemistry and Center for Innovative Technology; Vanderbilt University, Nashville, TN, USA., Sherrod SD; Department of Chemistry and Center for Innovative Technology; Vanderbilt University, Nashville, TN, USA., McLean JA; Department of Chemistry and Center for Innovative Technology; Vanderbilt University, Nashville, TN, USA., Trapani JB; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Cottam MA; The Vanderbilt Creative Data Solutions Shared Resource, Vanderbilt University, Nashville, TN, USA., Wan M; Epigenetics and RNA Biology Laboratory and Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Shrivastava D; Epigenetics and RNA Biology Laboratory and Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Delker DA; Epigenetics and RNA Biology Laboratory and Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Wilson MH; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.; Research and Medical Services, Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., Hasenour CM; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Lantier L; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Chernova I; Section of Nephrology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Young JD; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Haase VH; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.; Research and Medical Services, Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Vazquez-Medina JP; Department of Integrative Biology, University of California, Berkeley, CA, USA., Kosma DK; Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, USA.; Hitchcock Center for Chemical Ecology, University of Nevada, Reno, NV, USA., Kim PK; Cell Biology Program, Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Cartailler JP; The Vanderbilt Creative Data Solutions Shared Resource, Vanderbilt University, Nashville, TN, USA., Zhang M; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Zent R; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.; Research and Medical Services, Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., Harris RC; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.; Research and Medical Services, Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., Watts JA; Epigenetics and RNA Biology Laboratory and Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Terker AS; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Bock F; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA., Rathmell JC; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA., Rodan AR; Molecular Medicine Program, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA.; Division of Nephrology & Hypertension, Department of Internal Medicine, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA.; Medical Service, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah, USA., Arroyo JP; Division of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA. juan.p.arroyo@vumc.org.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA. juan.p.arroyo@vumc.org.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA. juan.p.arroyo@vumc.org.
Source: Nature communications [Nat Commun] 2026 May 25; Vol. 17 (1). Date of Electronic Publication: 2026 May 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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