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Efficacy, Structure-Activity Relationship, and Mode of Action Studies of a New Generation of Acridine/Acridone-Based Antimalarials.

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Title: Efficacy, Structure-Activity Relationship, and Mode of Action Studies of a New Generation of Acridine/Acridone-Based Antimalarials.
Authors: Maluf SEC; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil., Mendes GR; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil., Moura IMR; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil., de Souza GE; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil., Valdes TA; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil., Bonatto V; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil., Oliveira GS; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil., Aguiar ACC; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, CEP 04023-062, Brazil., Gazarini ML; Department of Biosciences, Federal University of São Paulo, Santos 11015-020, Brazil., Puhl AC; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States., Monakhova N; Research Center of Biotechnology RAS, 33-2 Leninsky prospect, Moscow 119071, Russia., Lepioshkin A; Research Center of Biotechnology RAS, 33-2 Leninsky prospect, Moscow 119071, Russia., Makarov V; Research Center of Biotechnology RAS, 33-2 Leninsky prospect, Moscow 119071, Russia., Lane TR; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States., Raman R; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States., Campolina GAS; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, CEP 04023-062, Brazil., Barbosa CS; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, CEP 04023-062, Brazil., Ferreira ADS; Oswaldo Cruz Foundation, Leishmaniasis and Malaria Bioassay Platform, Porto Velho 76812-245, Brazil., Teles CBG; Oswaldo Cruz Foundation, Leishmaniasis and Malaria Bioassay Platform, Porto Velho 76812-245, Brazil., Pereira DB; Research Center in Tropical Medicine of Rondônia, Porto Velho 76812-329, Brazil., Barros RRM; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, CEP 04023-062, Brazil., Benavente ED; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, CS 3584, The Netherlands., Ekins S; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States., Guido RVC; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.
Source: ACS infectious diseases [ACS Infect Dis] 2026 Jun 12; Vol. 12 (6), pp. 1866-1883. Date of Electronic Publication: 2026 May 25.
Publication Type: Journal Article
Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Maluf+SEC%22">Maluf SEC</searchLink>; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Mendes+GR%22">Mendes GR</searchLink>; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Moura+IMR%22">Moura IMR</searchLink>; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Souza+GE%22">de Souza GE</searchLink>; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Valdes+TA%22">Valdes TA</searchLink>; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Bonatto+V%22">Bonatto V</searchLink>; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Oliveira+GS%22">Oliveira GS</searchLink>; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Aguiar+ACC%22">Aguiar ACC</searchLink>; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, CEP 04023-062, Brazil.<br /><searchLink fieldCode="AU" term="%22Gazarini+ML%22">Gazarini ML</searchLink>; Department of Biosciences, Federal University of São Paulo, Santos 11015-020, Brazil.<br /><searchLink fieldCode="AU" term="%22Puhl+AC%22">Puhl AC</searchLink>; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.<br /><searchLink fieldCode="AU" term="%22Monakhova+N%22">Monakhova N</searchLink>; Research Center of Biotechnology RAS, 33-2 Leninsky prospect, Moscow 119071, Russia.<br /><searchLink fieldCode="AU" term="%22Lepioshkin+A%22">Lepioshkin A</searchLink>; Research Center of Biotechnology RAS, 33-2 Leninsky prospect, Moscow 119071, Russia.<br /><searchLink fieldCode="AU" term="%22Makarov+V%22">Makarov V</searchLink>; Research Center of Biotechnology RAS, 33-2 Leninsky prospect, Moscow 119071, Russia.<br /><searchLink fieldCode="AU" term="%22Lane+TR%22">Lane TR</searchLink>; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.<br /><searchLink fieldCode="AU" term="%22Raman+R%22">Raman R</searchLink>; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.<br /><searchLink fieldCode="AU" term="%22Campolina+GAS%22">Campolina GAS</searchLink>; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, CEP 04023-062, Brazil.<br /><searchLink fieldCode="AU" term="%22Barbosa+CS%22">Barbosa CS</searchLink>; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, CEP 04023-062, Brazil.<br /><searchLink fieldCode="AU" term="%22Ferreira+ADS%22">Ferreira ADS</searchLink>; Oswaldo Cruz Foundation, Leishmaniasis and Malaria Bioassay Platform, Porto Velho 76812-245, Brazil.<br /><searchLink fieldCode="AU" term="%22Teles+CBG%22">Teles CBG</searchLink>; Oswaldo Cruz Foundation, Leishmaniasis and Malaria Bioassay Platform, Porto Velho 76812-245, Brazil.<br /><searchLink fieldCode="AU" term="%22Pereira+DB%22">Pereira DB</searchLink>; Research Center in Tropical Medicine of Rondônia, Porto Velho 76812-329, Brazil.<br /><searchLink fieldCode="AU" term="%22Barros+RRM%22">Barros RRM</searchLink>; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, CEP 04023-062, Brazil.<br /><searchLink fieldCode="AU" term="%22Benavente+ED%22">Benavente ED</searchLink>; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, CS 3584, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ekins+S%22">Ekins S</searchLink>; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.<br /><searchLink fieldCode="AU" term="%22Guido+RVC%22">Guido RVC</searchLink>; São Carlos Institute of Physics, University of São Paulo, São Carlos 13563-120, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101654580%22">ACS infectious diseases</searchLink> [ACS Infect Dis] 2026 Jun 12; Vol. 12 (6), pp. 1866-1883. <i>Date of Electronic Publication: </i>2026 May 25.
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