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Phenotype Refinement Influences GWAS-Implicated Variant Effect Sizes for Insomnia.

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Title: Phenotype Refinement Influences GWAS-Implicated Variant Effect Sizes for Insomnia.
Authors: Zimmerman AJ; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Divisions of Human Genetics and Diabetes & Endocrinology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Liu PZ; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Keenan BT; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Brooks TG; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Grant SFA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Divisions of Human Genetics and Diabetes & Endocrinology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Gehrman PR; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Anafi RC; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Pack AI; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Source: Journal of sleep research [J Sleep Res] 2026 May 26, pp. e70356. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Published on behalf of the European Sleep Research Society by Blackwell Scientific Publications Country of Publication: England NLM ID: 9214441 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2869 (Electronic) Linking ISSN: 09621105 NLM ISO Abbreviation: J Sleep Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zimmerman+AJ%22">Zimmerman AJ</searchLink>; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Divisions of Human Genetics and Diabetes & Endocrinology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Liu+PZ%22">Liu PZ</searchLink>; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Keenan+BT%22">Keenan BT</searchLink>; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Brooks+TG%22">Brooks TG</searchLink>; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Grant+SFA%22">Grant SFA</searchLink>; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Divisions of Human Genetics and Diabetes & Endocrinology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Gehrman+PR%22">Gehrman PR</searchLink>; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Anafi+RC%22">Anafi RC</searchLink>; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Pack+AI%22">Pack AI</searchLink>; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
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        Value: 10.1111/jsr.70356
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              Text: 2026 May 26
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