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Is SORL1 a common genetic target across neurodegenerative diseases? A multi-ancestry biobank study.

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Title: Is SORL1 a common genetic target across neurodegenerative diseases? A multi-ancestry biobank study.
Authors: Khani M; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Yeboah SN; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Cerquera-Cleves C; Department of Neurosciences, Neurology Unit, Hospital Universitario San Ignacio, Bogotá, Colombia.; CHU de Québec Research Center, Axe Neurosciences, Laval University, Québec City, Québec, QC G1V 4G2, Canada., Kedmi A; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Bustos BI; Ken and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Grant SM; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Can Akerman S; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Akçimen F; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, and National Institutes of Health, Bethesda, MD 20892, USA., Lee PS; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Reyes-Pérez P; Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Campus UNAM 3001, Juriquilla, QRO 76230, México., Lange LM; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, and National Institutes of Health, Bethesda, MD 20892, USA., Leonard H; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Data Tecnica LLC, Washington, DC 20037, USA., Koretsky MJ; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Data Tecnica LLC, Washington, DC 20037, USA., Makarious MB; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Data Tecnica LLC, Washington, DC 20037, USA., Schneider Z; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Jonson C; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Data Tecnica LLC, Washington, DC 20037, USA., Chen PS; Department of Neurology, National Taiwan University Hospital Bei-Hu branch, Taipei 114, Taiwan., Tay YW; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia., Rothstein JD; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Lin CH; Department of Neurology, National Taiwan University Hospital, Taipei 100, Taiwan., Lim SY; Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia., Klein C; Institute of Neurogenetics, University of Lübeck, Lübeck 23538, Germany., Merchant K; Ken and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Mencacci NE; Ken and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Krainc D; Ken and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Cookson MR; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, and National Institutes of Health, Bethesda, MD 20892, USA., Singleton A; Global Parkinson's Genetics Program, USA., Bandres-Ciga S; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Source: Brain : a journal of neurology [Brain] 2026 May 26. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Is SORL1 a common genetic target across neurodegenerative diseases? A multi-ancestry biobank study.
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  Data: <searchLink fieldCode="AU" term="%22Khani+M%22">Khani M</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Yeboah+SN%22">Yeboah SN</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Cerquera-Cleves+C%22">Cerquera-Cleves C</searchLink>; Department of Neurosciences, Neurology Unit, Hospital Universitario San Ignacio, Bogotá, Colombia.; CHU de Québec Research Center, Axe Neurosciences, Laval University, Québec City, Québec, QC G1V 4G2, Canada.<br /><searchLink fieldCode="AU" term="%22Kedmi+A%22">Kedmi A</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Bustos+BI%22">Bustos BI</searchLink>; Ken and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Grant+SM%22">Grant SM</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Can+Akerman+S%22">Can Akerman S</searchLink>; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Akçimen+F%22">Akçimen F</searchLink>; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, and National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Lee+PS%22">Lee PS</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Reyes-Pérez+P%22">Reyes-Pérez P</searchLink>; Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Campus UNAM 3001, Juriquilla, QRO 76230, México.<br /><searchLink fieldCode="AU" term="%22Lange+LM%22">Lange LM</searchLink>; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, and National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Leonard+H%22">Leonard H</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Data Tecnica LLC, Washington, DC 20037, USA.<br /><searchLink fieldCode="AU" term="%22Koretsky+MJ%22">Koretsky MJ</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Data Tecnica LLC, Washington, DC 20037, USA.<br /><searchLink fieldCode="AU" term="%22Makarious+MB%22">Makarious MB</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Data Tecnica LLC, Washington, DC 20037, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+Z%22">Schneider Z</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Jonson+C%22">Jonson C</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Data Tecnica LLC, Washington, DC 20037, USA.<br /><searchLink fieldCode="AU" term="%22Chen+PS%22">Chen PS</searchLink>; Department of Neurology, National Taiwan University Hospital Bei-Hu branch, Taipei 114, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tay+YW%22">Tay YW</searchLink>; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.<br /><searchLink fieldCode="AU" term="%22Rothstein+JD%22">Rothstein JD</searchLink>; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; Department of Neurology, National Taiwan University Hospital, Taipei 100, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lim+SY%22">Lim SY</searchLink>; Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.<br /><searchLink fieldCode="AU" term="%22Klein+C%22">Klein C</searchLink>; Institute of Neurogenetics, University of Lübeck, Lübeck 23538, Germany.<br /><searchLink fieldCode="AU" term="%22Merchant+K%22">Merchant K</searchLink>; Ken and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Mencacci+NE%22">Mencacci NE</searchLink>; Ken and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Krainc+D%22">Krainc D</searchLink>; Ken and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Cookson+MR%22">Cookson MR</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, and National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Singleton+A%22">Singleton A</searchLink>; Global Parkinson's Genetics Program, USA.<br /><searchLink fieldCode="AU" term="%22Bandres-Ciga+S%22">Bandres-Ciga S</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
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