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A2A Receptor Activation Restores Lipid and Mitochondrial Homeostasis, Limiting Mycobacterium leprae Persistence in Human Monocytes.

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Title: A2A Receptor Activation Restores Lipid and Mitochondrial Homeostasis, Limiting Mycobacterium leprae Persistence in Human Monocytes.
Authors: Pereira AMR; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Santos PMFD; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Rosa TLSA; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Díaz Acosta C; Department of Molecular Biology and Biotechnology, Health Sciences Research Institute (IICS), National University of Asunción, Asunción 111421, Paraguay., Vasconcelos KGC; Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago 8580745, Chile.; Gerosciense Center for Brain Health and Metabolism (GERO), Santiago 8580745, Chile., Gutierres LD; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Costa FMR; Laboratory of Immunopathology, Medical Sciences Faculty, Rio de Janeiro State University (FCM/UERJ), Rio de Janeiro 20550-900, Brazil., Lery LMS; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Garrett R; Metabolomics Laboratory, Institute of Chemistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-909, Brazil., Alves MA; Laboratory of Metabolomics Applied to Systems Medicine, Natural Products Research Institute, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-909, Brazil., Dias AA; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Lara FA; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Rodrigues LS; Laboratory of Immunopathology, Medical Sciences Faculty, Rio de Janeiro State University (FCM/UERJ), Rio de Janeiro 20550-900, Brazil., Pinheiro RO; Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Pessolani MCV; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Berrêdo-Pinho M; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil.
Source: Metabolites [Metabolites] 2026 Apr 29; Vol. 16 (5). Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A<subscript>2A</subscript> Receptor Activation Restores Lipid and Mitochondrial Homeostasis, Limiting Mycobacterium leprae Persistence in Human Monocytes.
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  Data: <searchLink fieldCode="AU" term="%22Pereira+AMR%22">Pereira AMR</searchLink>; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Santos+PMFD%22">Santos PMFD</searchLink>; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Rosa+TLSA%22">Rosa TLSA</searchLink>; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Díaz+Acosta+C%22">Díaz Acosta C</searchLink>; Department of Molecular Biology and Biotechnology, Health Sciences Research Institute (IICS), National University of Asunción, Asunción 111421, Paraguay.<br /><searchLink fieldCode="AU" term="%22Vasconcelos+KGC%22">Vasconcelos KGC</searchLink>; Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago 8580745, Chile.; Gerosciense Center for Brain Health and Metabolism (GERO), Santiago 8580745, Chile.<br /><searchLink fieldCode="AU" term="%22Gutierres+LD%22">Gutierres LD</searchLink>; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Costa+FMR%22">Costa FMR</searchLink>; Laboratory of Immunopathology, Medical Sciences Faculty, Rio de Janeiro State University (FCM/UERJ), Rio de Janeiro 20550-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Lery+LMS%22">Lery LMS</searchLink>; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Garrett+R%22">Garrett R</searchLink>; Metabolomics Laboratory, Institute of Chemistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-909, Brazil.<br /><searchLink fieldCode="AU" term="%22Alves+MA%22">Alves MA</searchLink>; Laboratory of Metabolomics Applied to Systems Medicine, Natural Products Research Institute, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-909, Brazil.<br /><searchLink fieldCode="AU" term="%22Dias+AA%22">Dias AA</searchLink>; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Lara+FA%22">Lara FA</searchLink>; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodrigues+LS%22">Rodrigues LS</searchLink>; Laboratory of Immunopathology, Medical Sciences Faculty, Rio de Janeiro State University (FCM/UERJ), Rio de Janeiro 20550-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Pinheiro+RO%22">Pinheiro RO</searchLink>; Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Pessolani+MCV%22">Pessolani MCV</searchLink>; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Berrêdo-Pinho+M%22">Berrêdo-Pinho M</searchLink>; Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101578790%22">Metabolites</searchLink> [Metabolites] 2026 Apr 29; Vol. 16 (5). <i>Date of Electronic Publication: </i>2026 Apr 29.
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