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Genome-wide association mapping and targeted loss of function studies identify Shroom3 as a driver of hyperpolyploidy and ventricular dilation.

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Title: Genome-wide association mapping and targeted loss of function studies identify Shroom3 as a driver of hyperpolyploidy and ventricular dilation.
Authors: Purdy AL; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226., Bakhshian Nik A; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226., Arkatkar AA; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226., Hasan P; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226., Flinn MA; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226., Choudhury P; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226., Wood C; Center for Innovative Design and Analysis, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045., Takizawa A; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226., Malloy L; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226., Tutaj M; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226., Drysdale TA; Children's Health Research Institute, Victoria Research Labs, London, ON N6A 4L6, Canada.; Department of Physiology and Pharmacology, The University of Western Ontario, London, ON N6A 3K7, Canada.; Department of Paediatrics, The University of Western Ontario, London, ON N6A 3K7, Canada., Bridgewater D; Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada., Link BA; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226., Plageman TF Jr; College of Optometry, The Ohio State University, Columbus, OH 43210., Kwitek AE; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226., Dwinell MR; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226., Saba LM; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045., O'Meara CC; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226., Patterson M; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 02; Vol. 123 (22), pp. e2522068123. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Purdy+AL%22">Purdy AL</searchLink>; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Bakhshian+Nik+A%22">Bakhshian Nik A</searchLink>; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Arkatkar+AA%22">Arkatkar AA</searchLink>; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Hasan+P%22">Hasan P</searchLink>; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Flinn+MA%22">Flinn MA</searchLink>; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Choudhury+P%22">Choudhury P</searchLink>; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Wood+C%22">Wood C</searchLink>; Center for Innovative Design and Analysis, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.<br /><searchLink fieldCode="AU" term="%22Takizawa+A%22">Takizawa A</searchLink>; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Malloy+L%22">Malloy L</searchLink>; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Tutaj+M%22">Tutaj M</searchLink>; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Drysdale+TA%22">Drysdale TA</searchLink>; Children's Health Research Institute, Victoria Research Labs, London, ON N6A 4L6, Canada.; Department of Physiology and Pharmacology, The University of Western Ontario, London, ON N6A 3K7, Canada.; Department of Paediatrics, The University of Western Ontario, London, ON N6A 3K7, Canada.<br /><searchLink fieldCode="AU" term="%22Bridgewater+D%22">Bridgewater D</searchLink>; Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.<br /><searchLink fieldCode="AU" term="%22Link+BA%22">Link BA</searchLink>; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Plageman+TF+Jr%22">Plageman TF Jr</searchLink>; College of Optometry, The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Kwitek+AE%22">Kwitek AE</searchLink>; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Dwinell+MR%22">Dwinell MR</searchLink>; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Saba+LM%22">Saba LM</searchLink>; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.<br /><searchLink fieldCode="AU" term="%22O'Meara+CC%22">O'Meara CC</searchLink>; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Patterson+M%22">Patterson M</searchLink>; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226.
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