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In vivo analysis of trafficking and functional impact of hERG pore-domain missense variants in a CRISPR/Cas9-engineered Celegans model of long QT syndrome.

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Title: In vivo analysis of trafficking and functional impact of hERG pore-domain missense variants in a CRISPR/Cas9-engineered Celegans model of long QT syndrome.
Authors: Delinière A; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France; Centre de référence national des troubles du rythme cardiaque héréditaires ou rares de Lyon, Institut de Cardiologie, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, France; Service de Rythmologie, Institut de Cardiologie des Hospices Civils de Lyon, Hôpital Louis Pradel, Bron, France., Boiteux C; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France; Centre de référence national des troubles du rythme cardiaque héréditaires ou rares de Lyon, Institut de Cardiologie, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, France; Service de Rythmologie, Institut de Cardiologie des Hospices Civils de Lyon, Hôpital Louis Pradel, Bron, France., Blancfuney C; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France., Hysa S; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France., Martín LR; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France., Sechi S; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France., Nevoret E; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France., Chevalier P; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France; Centre de référence national des troubles du rythme cardiaque héréditaires ou rares de Lyon, Institut de Cardiologie, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, France; Service de Rythmologie, Institut de Cardiologie des Hospices Civils de Lyon, Hôpital Louis Pradel, Bron, France., Boulin T; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France., Andrini O; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France; Institut Universitaire de France, Paris, France. Electronic address: olga.andrini@univ-lyon1.fr.
Source: Heart rhythm [Heart Rhythm] 2026 May 25. Date of Electronic Publication: 2026 May 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101200317 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-3871 (Electronic) Linking ISSN: 15475271 NLM ISO Abbreviation: Heart Rhythm Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In vivo analysis of trafficking and functional impact of hERG pore-domain missense variants in a CRISPR/Cas9-engineered Celegans model of long QT syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Delinière+A%22">Delinière A</searchLink>; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France; Centre de référence national des troubles du rythme cardiaque héréditaires ou rares de Lyon, Institut de Cardiologie, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, France; Service de Rythmologie, Institut de Cardiologie des Hospices Civils de Lyon, Hôpital Louis Pradel, Bron, France.<br /><searchLink fieldCode="AU" term="%22Boiteux+C%22">Boiteux C</searchLink>; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France; Centre de référence national des troubles du rythme cardiaque héréditaires ou rares de Lyon, Institut de Cardiologie, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, France; Service de Rythmologie, Institut de Cardiologie des Hospices Civils de Lyon, Hôpital Louis Pradel, Bron, France.<br /><searchLink fieldCode="AU" term="%22Blancfuney+C%22">Blancfuney C</searchLink>; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Hysa+S%22">Hysa S</searchLink>; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Martín+LR%22">Martín LR</searchLink>; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Sechi+S%22">Sechi S</searchLink>; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Nevoret+E%22">Nevoret E</searchLink>; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Chevalier+P%22">Chevalier P</searchLink>; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France; Centre de référence national des troubles du rythme cardiaque héréditaires ou rares de Lyon, Institut de Cardiologie, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, France; Service de Rythmologie, Institut de Cardiologie des Hospices Civils de Lyon, Hôpital Louis Pradel, Bron, France.<br /><searchLink fieldCode="AU" term="%22Boulin+T%22">Boulin T</searchLink>; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Andrini+O%22">Andrini O</searchLink>; Université Lyon 1, CNRS, INSERM, MeLiS, UMR5284, UMR S1314, Lyon, France; Institut Universitaire de France, Paris, France. Electronic address: olga.andrini@univ-lyon1.fr.
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        Value: 10.1016/j.hrthm.2026.05.031
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              Text: 2026 May 25
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