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Mitochondrial oxidative phosphorylation inhibition by 9α,11α-dihydroxy-kaurenoic acid promotes ROS-associated apoptosis and suppresses cancer stemness in non-small cell lung cancer.

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Title: Mitochondrial oxidative phosphorylation inhibition by 9α,11α-dihydroxy-kaurenoic acid promotes ROS-associated apoptosis and suppresses cancer stemness in non-small cell lung cancer.
Authors: Wu KC; School of Pharmacy, College of Pharmacy, China Medical University, Taichung, 406040, Taiwan., Liu YC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan., Weng JR; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.; Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan., Lu TL; School of Pharmacy, College of Pharmacy, China Medical University, Taichung, 406040, Taiwan., Chang FP; School of Pharmacy, College of Pharmacy, China Medical University, Taichung, 406040, Taiwan., Cai YX; School of Pharmacy, College of Pharmacy, China Medical University, Taichung, 406040, Taiwan., Tsai BY; School of Pharmacy, College of Pharmacy, China Medical University, Taichung, 406040, Taiwan., Lu MT; Department of Cosmeceutics, Graduate Institute of Cosmeceutics, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist, Taichung, 406040, Taiwan., Chu PC; Department of Cosmeceutics, Graduate Institute of Cosmeceutics, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist, Taichung, 406040, Taiwan. popopi@gmail.com.
Source: Scientific reports [Sci Rep] 2026 May 27. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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        Value: 10.1038/s41598-026-55357-4
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              Text: 2026 May 27
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