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Mechanosensitive FHL2 tunes endothelial function via microtubule-actomyosin crosstalk.

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Title: Mechanosensitive FHL2 tunes endothelial function via microtubule-actomyosin crosstalk.
Authors: Seetharaman S; Department of Physics, The University of Chicago, Chicago, IL, USA. shailaja@nus.edu.sg.; James Franck Institute, The University of Chicago, Chicago, IL, USA. shailaja@nus.edu.sg.; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA. shailaja@nus.edu.sg.; Mechanobiology Institute, National University of Singapore, Singapore, Singapore. shailaja@nus.edu.sg.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. shailaja@nus.edu.sg., Devany J; Department of Physics, The University of Chicago, Chicago, IL, USA.; James Franck Institute, The University of Chicago, Chicago, IL, USA.; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA., Kim HR; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA.; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., van Bodegraven EJ; Department of Translational Neuroscience, Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Chmiel T; Department of Physics, The University of Chicago, Chicago, IL, USA.; James Franck Institute, The University of Chicago, Chicago, IL, USA., Tzu-Pin S; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Chou WH; James Franck Institute, The University of Chicago, Chicago, IL, USA.; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.; Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL, USA., Fang Y; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Gardel ML; Department of Physics, The University of Chicago, Chicago, IL, USA. gardel@uchicago.edu.; James Franck Institute, The University of Chicago, Chicago, IL, USA. gardel@uchicago.edu.; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA. gardel@uchicago.edu.; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA. gardel@uchicago.edu.; Molecular Genetics & Cell Biology, The University of Chicago, Chicago, IL, USA. gardel@uchicago.edu.; Biohub, Chicago, IL, USA. gardel@uchicago.edu.
Source: The EMBO journal [EMBO J] 2026 Jul; Vol. 45 (13), pp. 4569-4604. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mechanosensitive FHL2 tunes endothelial function via microtubule-actomyosin crosstalk.
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  Data: <searchLink fieldCode="AU" term="%22Seetharaman+S%22">Seetharaman S</searchLink>; Department of Physics, The University of Chicago, Chicago, IL, USA. shailaja@nus.edu.sg.; James Franck Institute, The University of Chicago, Chicago, IL, USA. shailaja@nus.edu.sg.; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA. shailaja@nus.edu.sg.; Mechanobiology Institute, National University of Singapore, Singapore, Singapore. shailaja@nus.edu.sg.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. shailaja@nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Devany+J%22">Devany J</searchLink>; Department of Physics, The University of Chicago, Chicago, IL, USA.; James Franck Institute, The University of Chicago, Chicago, IL, USA.; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Kim+HR%22">Kim HR</searchLink>; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA.; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22van+Bodegraven+EJ%22">van Bodegraven EJ</searchLink>; Department of Translational Neuroscience, Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Chmiel+T%22">Chmiel T</searchLink>; Department of Physics, The University of Chicago, Chicago, IL, USA.; James Franck Institute, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Tzu-Pin+S%22">Tzu-Pin S</searchLink>; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chou+WH%22">Chou WH</searchLink>; James Franck Institute, The University of Chicago, Chicago, IL, USA.; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.; Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Fang+Y%22">Fang Y</searchLink>; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Gardel+ML%22">Gardel ML</searchLink>; Department of Physics, The University of Chicago, Chicago, IL, USA. gardel@uchicago.edu.; James Franck Institute, The University of Chicago, Chicago, IL, USA. gardel@uchicago.edu.; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA. gardel@uchicago.edu.; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA. gardel@uchicago.edu.; Molecular Genetics & Cell Biology, The University of Chicago, Chicago, IL, USA. gardel@uchicago.edu.; Biohub, Chicago, IL, USA. gardel@uchicago.edu.
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              Text: 2026 Jul
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