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NeoCircle: pre- and post-operative circulating tumor DNA dynamics predicts survival in neoadjuvant-treated early breast cancer.

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Title: NeoCircle: pre- and post-operative circulating tumor DNA dynamics predicts survival in neoadjuvant-treated early breast cancer.
Authors: George AM; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.; SAGA Diagnostics, Morrisville, NC, USA., Chen Y; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; SAGA Diagnostics, Morrisville, NC, USA., Gladchuk S; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.; SAGA Diagnostics, Morrisville, NC, USA., Alcaide M; SAGA Diagnostics, Morrisville, NC, USA., Dalal H; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden., Meng P; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden., Brueffer C; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden., Saghir H; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; SAGA Diagnostics, Morrisville, NC, USA., Kimbung S; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden., Aaltonen K; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden., Oton L; SAGA Diagnostics, Morrisville, NC, USA., Rushton C; SAGA Diagnostics, Morrisville, NC, USA., Birkeälv S; SAGA Diagnostics, Morrisville, NC, USA., Jönsson M; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden., Zackrisson S; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.; Diagnostic Radiology, Department of Translational Medicine, Lund University, Malmö, Sweden.; Department of Imaging and Physiology, Skåne University Hospital, Malmö, Sweden., Skarping I; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden., Förnvik D; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.; Medical Radiation Physics, Department of Translational Medicine, Lund University, Malmö, Sweden.; Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund/Malmö, Sweden., Zander L; Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund/Malmö, Sweden., Honeth G; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Department of Pathology, Skåne University Hospital, Lund, Sweden., Woodhouse S; SAGA Diagnostics, Morrisville, NC, USA., Howarth K; SAGA Diagnostics, Morrisville, NC, USA., Borg Å; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden., Ehinger A; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Department of Pathology, Skåne University Hospital, Lund, Sweden., Malmberg M; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden., Rydén L; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.; Department of Surgery, Skåne University Hospital, Lund, Sweden., Loman N; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.; Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund/Malmö, Sweden., Saal LH; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden. lao.saal@med.lu.se.; Lund University Cancer Center, Lund, Sweden. lao.saal@med.lu.se.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden. lao.saal@med.lu.se.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden. lao.saal@med.lu.se.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jul; Vol. 18 (7), pp. 2617-2634. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: NeoCircle: pre- and post-operative circulating tumor DNA dynamics predicts survival in neoadjuvant-treated early breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22George+AM%22">George AM</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.; SAGA Diagnostics, Morrisville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; SAGA Diagnostics, Morrisville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Gladchuk+S%22">Gladchuk S</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.; SAGA Diagnostics, Morrisville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Alcaide+M%22">Alcaide M</searchLink>; SAGA Diagnostics, Morrisville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Dalal+H%22">Dalal H</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Meng+P%22">Meng P</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Brueffer+C%22">Brueffer C</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Saghir+H%22">Saghir H</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; SAGA Diagnostics, Morrisville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kimbung+S%22">Kimbung S</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Aaltonen+K%22">Aaltonen K</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Oton+L%22">Oton L</searchLink>; SAGA Diagnostics, Morrisville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Rushton+C%22">Rushton C</searchLink>; SAGA Diagnostics, Morrisville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Birkeälv+S%22">Birkeälv S</searchLink>; SAGA Diagnostics, Morrisville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Jönsson+M%22">Jönsson M</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Zackrisson+S%22">Zackrisson S</searchLink>; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.; Diagnostic Radiology, Department of Translational Medicine, Lund University, Malmö, Sweden.; Department of Imaging and Physiology, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Skarping+I%22">Skarping I</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Förnvik+D%22">Förnvik D</searchLink>; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.; Medical Radiation Physics, Department of Translational Medicine, Lund University, Malmö, Sweden.; Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund/Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Zander+L%22">Zander L</searchLink>; Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund/Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Honeth+G%22">Honeth G</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Department of Pathology, Skåne University Hospital, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Woodhouse+S%22">Woodhouse S</searchLink>; SAGA Diagnostics, Morrisville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Howarth+K%22">Howarth K</searchLink>; SAGA Diagnostics, Morrisville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Borg+Å%22">Borg Å</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Ehinger+A%22">Ehinger A</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Department of Pathology, Skåne University Hospital, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Malmberg+M%22">Malmberg M</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Rydén+L%22">Rydén L</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.; Department of Surgery, Skåne University Hospital, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Loman+N%22">Loman N</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University Cancer Center, Lund, Sweden.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden.; Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund/Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Saal+LH%22">Saal LH</searchLink>; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden. lao.saal@med.lu.se.; Lund University Cancer Center, Lund, Sweden. lao.saal@med.lu.se.; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden. lao.saal@med.lu.se.; Center for Interdisciplinary Research on Cancer and Equity in Women, Lund University, Lund, Sweden. lao.saal@med.lu.se.
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