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Machine learning, whole genome sequencing, and Mendelian randomization support a role of CRP on COVID-19 severity.

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Title: Machine learning, whole genome sequencing, and Mendelian randomization support a role of CRP on COVID-19 severity.
Authors: Lantieri F; Biostatistics Unit, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Croci S; Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Decherchi S; Fondazione Istituto Italiano di Tecnologia, Genoa, Italy., Rusmini M; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Recchi G; Rheumatology and Autoinflammatory Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Bonacini M; Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Ferrigno I; Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Rossi A; Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Castillo De Spelorzi YC; Genomics Facility, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy., Henzen E; Genomics Facility, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy., Rosamilia F; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Cangelosi D; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Landuzzi F; Computational Genomics, Center for Clinical and Computational Genomics (C3G), Italian Institute of Technology, Aosta, 11100 , Italy., Angius A; Institute of Genetics and Biomedical Research, National Research Council, University Campus of Cagliari, Monserrato, Cagliari, Italy., Rallo V; Institute of Genetics and Biomedical Research, National Research Council, University Campus of Cagliari, Monserrato, Cagliari, Italy., Mancuso P; Unit of Epidemiology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Pezzarossi A; Unit of Epidemiology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Giorgi Rossi P; Unit of Epidemiology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Catanoso M; Unit of Rheumatology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Gattorno M; Rheumatology and Autoinflammatory Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Cavalli A; Computational and Chemical Biology, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.; European Center for Atomic and Molecular Computing, Swiss Federal Institute of Technology, Lausanne, Lausanne, 1015, Switzerland., Meroni PL; Laboratory of Immunorheumatologic Researches, IRCCS Istituto Auxologico Italiano, Milan, Italy., Vozzi D; Genomics Facility, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy., Uva P; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Ceccherini I; UOSD Research Laboratories Aggregation Area, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini, Genoa, 5 - 16147, Italy. isabellaceccherini@gaslini.org., Salvarani C; Unit of Rheumatology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.; University of Modena and Reggio Emilia, Modena, Italy.
Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2026 May 27; Vol. 32 (1). Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658 (Electronic) Linking ISSN: 10761551 NLM ISO Abbreviation: Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Machine learning, whole genome sequencing, and Mendelian randomization support a role of CRP on COVID-19 severity.
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  Data: <searchLink fieldCode="AU" term="%22Lantieri+F%22">Lantieri F</searchLink>; Biostatistics Unit, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Croci+S%22">Croci S</searchLink>; Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Decherchi+S%22">Decherchi S</searchLink>; Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Rusmini+M%22">Rusmini M</searchLink>; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Recchi+G%22">Recchi G</searchLink>; Rheumatology and Autoinflammatory Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Bonacini+M%22">Bonacini M</searchLink>; Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrigno+I%22">Ferrigno I</searchLink>; Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+A%22">Rossi A</searchLink>; Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Castillo+De+Spelorzi+YC%22">Castillo De Spelorzi YC</searchLink>; Genomics Facility, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Henzen+E%22">Henzen E</searchLink>; Genomics Facility, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Rosamilia+F%22">Rosamilia F</searchLink>; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Cangelosi+D%22">Cangelosi D</searchLink>; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Landuzzi+F%22">Landuzzi F</searchLink>; Computational Genomics, Center for Clinical and Computational Genomics (C3G), Italian Institute of Technology, Aosta, 11100 , Italy.<br /><searchLink fieldCode="AU" term="%22Angius+A%22">Angius A</searchLink>; Institute of Genetics and Biomedical Research, National Research Council, University Campus of Cagliari, Monserrato, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Rallo+V%22">Rallo V</searchLink>; Institute of Genetics and Biomedical Research, National Research Council, University Campus of Cagliari, Monserrato, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Mancuso+P%22">Mancuso P</searchLink>; Unit of Epidemiology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Pezzarossi+A%22">Pezzarossi A</searchLink>; Unit of Epidemiology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Giorgi+Rossi+P%22">Giorgi Rossi P</searchLink>; Unit of Epidemiology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Catanoso+M%22">Catanoso M</searchLink>; Unit of Rheumatology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Gattorno+M%22">Gattorno M</searchLink>; Rheumatology and Autoinflammatory Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Cavalli+A%22">Cavalli A</searchLink>; Computational and Chemical Biology, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.; European Center for Atomic and Molecular Computing, Swiss Federal Institute of Technology, Lausanne, Lausanne, 1015, Switzerland.<br /><searchLink fieldCode="AU" term="%22Meroni+PL%22">Meroni PL</searchLink>; Laboratory of Immunorheumatologic Researches, IRCCS Istituto Auxologico Italiano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Vozzi+D%22">Vozzi D</searchLink>; Genomics Facility, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Uva+P%22">Uva P</searchLink>; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Ceccherini+I%22">Ceccherini I</searchLink>; UOSD Research Laboratories Aggregation Area, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini, Genoa, 5 - 16147, Italy. isabellaceccherini@gaslini.org.<br /><searchLink fieldCode="AU" term="%22Salvarani+C%22">Salvarani C</searchLink>; Unit of Rheumatology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.; University of Modena and Reggio Emilia, Modena, Italy.
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  Data: <searchLink fieldCode="JN" term="%229501023%22">Molecular medicine (Cambridge, Mass.)</searchLink> [Mol Med] 2026 May 27; Vol. 32 (1). <i>Date of Electronic Publication: </i>2026 May 27.
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