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RYR1+ skeletal muscle-derived extracellular vesicles are exercise responsive and associated with insulin action.

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Title: RYR1+ skeletal muscle-derived extracellular vesicles are exercise responsive and associated with insulin action.
Authors: Zhang X; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA. xin.zhang193@duke.edu.; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina, 27701, USA. xin.zhang193@duke.edu.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina, 27701, USA. xin.zhang193@duke.edu., Vann CG; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA., Bartlett DB; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Department of Health and Medical Sciences, University of Surrey, Guildford, UK., Khodabukus A; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA., Truskey GA; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA., Bursac N; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA., Houmard JA; Department of Kinesiology, Human Performance Laboratory, East Carolina University, Greenville, North Carolina, USA., Johnson JL; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA., Huffman KM; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, 27701, USA., Andonian BJ; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, 27701, USA., Kraus WE; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, 27701, USA., Kraus VB; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, 27701, USA.
Source: Journal of translational medicine [J Transl Med] 2026 May 26; Vol. 24 (1). Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: RYR1<superscript>+</superscript> skeletal muscle-derived extracellular vesicles are exercise responsive and associated with insulin action.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA. xin.zhang193@duke.edu.; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina, 27701, USA. xin.zhang193@duke.edu.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina, 27701, USA. xin.zhang193@duke.edu.<br /><searchLink fieldCode="AU" term="%22Vann+CG%22">Vann CG</searchLink>; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.<br /><searchLink fieldCode="AU" term="%22Bartlett+DB%22">Bartlett DB</searchLink>; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Department of Health and Medical Sciences, University of Surrey, Guildford, UK.<br /><searchLink fieldCode="AU" term="%22Khodabukus+A%22">Khodabukus A</searchLink>; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Truskey+GA%22">Truskey GA</searchLink>; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Bursac+N%22">Bursac N</searchLink>; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Houmard+JA%22">Houmard JA</searchLink>; Department of Kinesiology, Human Performance Laboratory, East Carolina University, Greenville, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+JL%22">Johnson JL</searchLink>; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.<br /><searchLink fieldCode="AU" term="%22Huffman+KM%22">Huffman KM</searchLink>; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, 27701, USA.<br /><searchLink fieldCode="AU" term="%22Andonian+BJ%22">Andonian BJ</searchLink>; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, 27701, USA.<br /><searchLink fieldCode="AU" term="%22Kraus+WE%22">Kraus WE</searchLink>; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, 27701, USA.<br /><searchLink fieldCode="AU" term="%22Kraus+VB%22">Kraus VB</searchLink>; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina, 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, 27701, USA.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 May 26; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 May 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12967-026-08215-w
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        Text: English
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      – TitleFull: RYR1+ skeletal muscle-derived extracellular vesicles are exercise responsive and associated with insulin action.
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            – D: 26
              M: 05
              Text: 2026 May 26
              Type: published
              Y: 2026
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